TyG Index Found to Be Strong Predictor of Hypertension Risk, unravels study
The triglyceride glucose (TyG) index independently correlates with increased risk for hypertension across various threshold diagnostic values. This was found in study by Hua Hao and colleagues in the International Journal of General Medicine. Hypertension is one of the most alarming global health disorders. Metabolic disorders, through insulin resistance as an intermediate phase, have now been well elucidated to associate with hypertension.
Data was obtained from 4,028 participants who received annual health checks in 2019. Insulin resistance was estimated using the TyG index and TyG-BMI, calculated based on the levels of triglyceride (TG), fasting plasma glucose (FPG), and body mass index (BMI). Hypertension was defined based on two thresholds of diagnosis: 140/90 mmHg and 130/80 mmHg. Logistic regression models were applied to assess the relationship between TyG and hypertension. The analysis also used restricted cubic spline models to explore dose-response relationships. The population was stratified according to BMI categories, with a particular emphasis on those with a BMI of 24.0-27.9 kg/m².
Results
At the 140/90 mmHg threshold, the risk of hypertension was:
2.87 times higher (OR=2.87; 95% CI: 2.11-3.91) in the Q4 group of TyG compared to Q1.
8.03 times higher (OR=8.03; 95% CI: 5.05-12.75) in the Q4 group of TyG-BMI compared to Q1.
At the 130/80 mmHg threshold, the risk of hypertension was:
2.93 times higher (OR=2.93; 95% CI: 2.34-3.68) in the Q4 group of TyG compared to Q1.
Twofold to 7.12-fold more risky (OR=7.12; 95% CI: 5.08-9.99) compared to the Q1 group of TyG-BMI for the Q4 group
Secondary Results:
BMI 24.0-27.9 kg/m²
The baseline characteristics of the participants were as follows:
Q4 group of TyG had at the 140/90 mmHg threshold
2.79 times risk for hypertension and its OR=2.79; 95% CI: 1.67-4.66
At the 130/80 mmHg threshold, the Q4 group of TyG was at risk for hypertension.
3.07 time risks and its OR=3.07; 95% CI: 2.05-4.60
TyG and TyG-BMI are powerful, independent predictors of hypertension in diagnosing different thresholds. Such findings serve to underpin the necessity for an early identification of such insulin resistance for its management to avoid both hypertension risk and other long-term cardiovascular outcomes.
Reference:
Hao H, Geng H, Ma M. Association Between Triglyceride Glucose Index and Hypertension According to Different Diagnostic Criteria. Int J Gen Med. 2025 Jan 6;18:43-53. doi: 10.2147/IJGM.S499194. PMID: 39801923; PMCID: PMC11720999.
