Effect of vitamin K2 on body fat and body mass in humans-Results of a 3-year study
The pathophysiology of fat metabolism and its related changes in body composition has since long been a widely studied domain among medical professionals. Recent research has put the focus on the interlink between fat metabolism and hemostasis of bone in humans. (1, 2)
In the last decade, extensive research has highlighted the fact that osteocalcin, an osteoblast-specific protein, plays an important role in fat as well as glucose metabolism in humans. (3,4) Previous studies, both in vivo and in vitro, have proved that uncarboxylated osteocalcin(Ucoc) helps in the breakdown of fat, thus reducing the body mass(5); whereas an increase in the levels of carboxylated osteocalcin reduces the rate of fat metabolism (6) leading to obesity. Contrary to such results, a few other studies have suggested regular supplementation with Vitamin K2 reduced total fat accumulation and serum triglycerides in rats (7). To date, human trials have provided contradicting results regarding the role of osteocalcin in fat metabolism.
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