Prescribing Proton Pump Inhibitors need paradigm shift in the practice
Proton-pump inhibitors (PPIs) appear to be innocuous enough to treat heartburn and gastric acid reflux over-the-counter for years, but new research suggests that these common medications could have untoward consequences. PPIs acts by reducing gastric acid production by irreversibly binding the Na + H + ATPase located on the surface of gastric parietal cells.
In one Indian study, PPI was used in 66.6% of the patients. Such rampant use of PPI costs almost 10% to 20% of total expenditure on medicines spent by patients. Many physicians were found to be ignorant of the adverse effects of PPI associated with inappropriate prescribing of the agents. (1,2,3)