Use of Probiotics in the Management of Hypertension - Exploring the Potential
Hypertension has become a common chronic medical condition affecting > 20% of adult population worldwide. It is certainly established to be a major contributing factor for increasing complications of metabolic syndrome by adding one or more comorbidities such as heart disease, stroke, chronic renal failure, myocardial infarction, blindness, and dementia. It is also known that hypertension is also often considered as a lifestyle disorder, and clinically classified as primary (essential) and secondary. Essential hypertension remains a major cause in about 90% - 95% of all cases of hypertension and it is believed to be caused due to genetic factors and nonspecific lifestyle, with exact aetiology and pathophysiology remains an opportunity yet to be fully defined. (1)
While by 2025, the total number of hypertensive patients is expected to increase to 1.56 billion globally (2) , emerging evidence is bringing out the important role of microbiota in hypertension and its treatment with probiotics. We review the spectrum of evidence reflecting the interplay of gut microbiota in the context of high blood pressure, hypertension associated co-morbidities and potential of probiotics in the therapeutic armamentarium of hypertension.