Neurobion Forte

Neurobion forte belongs to the pharmacological class of Vitamin B complex and therapy class of Multivitamin

Neurobion forte has been approved for the treatment of nerve damage symptoms relief, like pamamanhid (numbness) and tusok-tusok (tingling)

Neurobion forte contains Vitamins B1 + B6 + B12 that effectively nourish the nerves as well as protect and regenerate nerves

Neurobion forte is composed of Thiamine mononitrate (Vitamin B1), Pyridoxine hydrochloride (Vitamin B6), and Cyanocobalamin (Vitamin B12)

Thiamine mononitrate (Vitamin B1) has an essential role in the metabolism of carbohydrates and the maintenance of nerve fibers. Thiamine acts on endothelial cells and leads to reduction in intracellular protein glycation by redirecting the glycolytic flux. Thiamine is mainly the transport form of the vitamin, whereas phosphorylated thiamine derivatives b\ are active form of vitamin. Natural derivatives of thiamine phosphate, such as thiamine monophosphate (ThMP), thiamine diphosphate (ThDP), also sometimes called thiamine pyrophosphate (TPP), thiamine triphosphate (ThTP), and thiamine triphosphate (AThTP), that act as coenzymes in addition to each unique biological functions.

Pyridoxine hydrochloride (Vitamin B6) is significantly important for the metabolism of proteins and amino acids and helps in the formation of the nervous system neurotransmitter. . Vitamin B6 which is scientifically known as Pyridoxine hydrochloride , principally in its biologically active coenzyme form pyridoxal 5'-phosphate, is involved in a wide range of biochemical reactions, including the metabolism of amino acids and glycogen, the synthesis of nucleic acids, hemoglobin, sphingomyelin and other sphingolipids, and the synthesis of the neurotransmitters serotonin, dopamine, norepinephrine and gamma-aminobutyric acid (GABA)

Cyanocobalamin (Vitamin B12) plays a role in the maturation of cells and in the maintenance of the integrity of nerve cells. Vitamin B12 which is known as Cyanocobalamin also acts as a cofactor for methionine synthase and L-methyl malonyl-CoA mutase enzymes Vitamin B12 which is principally called Cyanocobalamin also act as a cofactor for methionine synthase and L-methyl malonyl-CoA mutase enzymes which helps in the synthesis of pyrimidine and purines

Cmax of Vitamin B6 is achieved within 5.5 hours

Half-life of Vitamin B12 is Approximately 6 days whereas the half-life of vitamin B6 is 15 to 20 days.

Neurobion Forte is a safe medication for consumption although may cause certain side effects like nausea, vomiting, diarrhea, and nerve damage if consumed in excess

Neurobion forte is available in India , USA, Mexico, Tanzania,

Neurobion Forte is available in the form of tablets as well as injection

Neurobion forte which contains Vitamins B1 + B6 + B12 plays an effective role in the treatment of nerve damage symptoms it has thiamine mononitrate (Vitamin B1) has an essential role in the metabolism of carbohydrates and the maintenance of nerve fibers. Thiamine acts on endothelial cells and leads to reduction in intracellular protein glycation by redirecting the glycolytic flux. Thiamine is mainly the transport form of the vitamin, whereas phosphorylated thiamine derivatives b are active form of vitamin. Natural derivatives of thiamine phosphate, such as thiamine monophosphate (ThMP), thiamine diphosphate (ThDP), also sometimes called thiamine pyrophosphate (TPP), thiamine triphosphate (ThTP), and thiamine triphosphate (AThTP), that act as coenzymes in addition to each unique biological functions.

Pyridoxine hydrochloride (Vitamin B6) is significantly important for the metabolism of proteins and amino acids and helps in the formation of the nervous system neurotransmitter. Vitamin B6 which is scientifically known as Pyridoxine hydrochloride, principally in its biologically active coenzyme form pyridoxal 5'-phosphate, is involved in a wide range of biochemical reactions, including the metabolism of amino acids and glycogen, the synthesis of nucleic acids, hemoglobin, sphingomyelin and other sphingolipids, and the synthesis of the neurotransmitters serotonin, dopamine, norepinephrine and gamma-aminobutyric acid (GABA)

Cyanocobalamin (Vitamin B12) plays a role in the maturation of cells and in the maintenance of the integrity of nerve cells. Vitamin B12 also acts as a cofactor for methionine synthase and L-methyl malonyl-CoA mutase enzymes Vitamin B12 which is known as Cyanocobalamin also act as a cofactor for methionine synthase and L-methyl malonyl-CoA mutase enzymes which helps in the synthesis of pyrimidine and purines

Duration of action of Neurobion forte is not available

Neurobion forte onset of action starts within 2 hours of administration

Neurobion forte which contains Vitamins B1 + B6 + B12 is indicated for following cases

• Diabetic neuropathy

• Neuralgias and neuritis

• Algias of rheumatic and traumatic origin

• Degenerative conditions of the spine or surgical operations carried out thereon

• Herpes zoster, hemicrania and facial paresis

• Nausea and vomiting during pregnancy

Neurobion forte which contains Vitamins B1 + B6 + B12 is available in the form of Film-coated tablets as well injection is administered either orally or intramuscularly.

Doctor will determine the appropriate dosage of Neurobion Forte tablets based on factors like your age, weight, medical history, allergies, and overall well-being. For adults, the recommended dose is one tablet per day, preferably taken after a meal.

Neurobion forte film coated tablet contains 100 mg of Vitamin B1, 100 mg of vitamin B6 and 5 mg of Vitamin B12

Neurobion forte contains 100 mg of Vitamin B1, 100 mg of vitamin B6, and 5 mg of Vitamin B12 and is available in the form of film-coated tablet as well as solution for injection.

Neurobion forte which contains Vitamins B1 + B6 + B12 Is contraindicated in patients who are hypersensitive to any of the excipient or active pharmaceutical ingredients present in the Neurobion

Also is contraindicated in children below 14 years of age

Contraindicated in lactose intolerant patients

Neurobion forte which contains Vitamins B1 + B6 + B12 has following warnings and precautions

1. It is not recommended to administer Neurobion forte injections with other medications in a mixed injection or infusion form as it may lead to incompatibility

2. Before the administration of the Neurobion forte it has to be ensured that it was stored in a cool dry place, not exceeding 30°C. The packaging should not be severely damaged

3. Since the Neurobion forte contains lactose and sucrose hence is not recommended for lactose-intolerant patients

When on Neurobion forte limit the consumption of alcohol as alcohol can increase the nervous system side effects 

On consumption of Neurobion forte Vitamins B1, B6 and B12 are secreted into human breast milk, but risks of overdose for the infant are not known although in individual cases, high doses of vitamin B6 (i.e. >600 mg daily), may inhibit the production of breast milk.

Toxicity:

General Neurobion forte is non-toxic and absolutely safe but Mild, transient diarrhea, polycythemia vera, peripheral vascular thrombosis, itching, transitory exanthema, a feeling of swelling of entire body, pulmonary edema and congestive heart failure in early treatment stages, anaphylactic shock and death have been observed after vitamin B12 administration

No known associated risk has been found regarding the use of Neurobion forte during pregnancy at the recommended dosage.

Neurobion forte is a safe drug for consumption with no such known food warning although should not be consumed if the patient is lactose intolerant 

1. Levo Dopa

Neurobion forte may decrease the effect of L- Dopa when administered in the patient on L-Dopa therapy

2. Pyridoxine antagonists/Vitamin 6 Antagonist

Drugs such as isoniazid, cycloserine, penicillamine, or hydralazine may decrease the efficacy of vitamin B6

3. Loop Diuretics

Long term use of loop diuretics like furosemide results in accelerated elimination of therefore decreased vitamin B1 serum level

4. Acyclovir

When acyclovir interacts with thiamine i.e, vitamin B1 increases the risk or severity of adverse effects

5. Abacavir:

Cyanocobalamin may decrease the excretion rate of Abacavir which could result in a higher serum level

Neurobion Forte is a safe medication for consumption although may cause certain side effects like:

Nausea, vomiting, diarrhea, and nerve damage if consumed in excess

Neurobion forte contains Vitamins B1 + B6 + B12, High doses of Vitamin B6 i.e, Pyridoxine can cause syndrome like Sensorial neuropathy which can be treated ultimately upon discontinuation of Neurobion forte

No such complexities are known for vitamin B1 and B12