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  • Semaglutide promising...

Semaglutide promising alternative treatment for chronic myopathy of hyperkalemic periodic paralysis: a case report

Dr Kartikeya KohliWritten by Dr Kartikeya Kohli Published On 2025-04-21T09:00:12+05:30  |  Updated On 21 April 2025 2:24 PM IST
Semaglutide promising alternative treatment  for chronic myopathy of hyperkalemic periodic paralysis: a case report
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Semaglutide promising alternative treatment for chronic myopathy of hyperkalemic periodic paralysis suggests a case report published in the BMC Nephrology.

Hyperkalemic Periodic Paralysis (HyperPP) is a rare autosomal dominant channelopathy characterized by episodic muscle weakness or paralysis, often triggered by elevated extracellular potassium levels. This condition is frequently linked to mutations in the SCN4A gene, encoding a skeletal muscle sodium channel.
Traditional management strategies, such as potassium avoidance, low-potassium diets, and carbonic anhydrase inhibitors like acetazolamide and diclofenamide, have provided limited long-term relief, particularly in addressing the progressive myopathy associated with the disease.
Case Report
A 48-year-old male with a confirmed SCN4A mutation (Threonine to Methionine at position 704) presented with longstanding muscle weakness. Symptom onset occurred in childhood, with progressive deterioration into permanent weakness by his thirties. Conventional therapies were ineffective. In 2023, the patient began weekly semaglutide injections for weight loss. Remarkable improvement in muscle strength and mobility was noted within a year, with the patient regaining the ability to rise unaided from a chair and walk at a normal pace.
Semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1 RA), is primarily indicated for type 2 diabetes and obesity. However, this case suggests its potential in neuromuscular disorders. GLP-1 RAs may exert anabolic effects on skeletal muscle through insulin-dependent and insulin-independent pathways, improving mitochondrial function, glucose uptake, and reducing inflammation—factors potentially beneficial in muscle channelopathies
This case provides preliminary evidence that semaglutide may reverse chronic myopathy in HyperPP patients. Larger studies are needed to evaluate its therapeutic potential, safety, and mechanisms in muscular channelopathies.

References:

Brand, K., Landry, D., Mulhern, J. et al. Semaglutide reverses the chronic myopathy of hyperkalemic periodic paralysis: a case report. BMC Nephrol 26, 179 (2025). https://doi.org/10.1186/s12882-025-04068-5
Hyperkalemic periodic paralysisSCN4A mutationSemaglutideMyopathyGLP-1 receptor agonistSkeletal muscleChannelopathyCase report
Source : BMC Nephrology
Dr Kartikeya Kohli
Dr Kartikeya Kohli

    Dr Kartikeya Kohli is an Internal Medicine Consultant at Sitaram Bhartia Hospital in Delhi with super speciality training in Nephrology. He has worked with various eminent hospitals like Indraprastha Apollo Hospital, Sir Gangaram Hospital. He holds an MBBS from Kasturba Medical College Manipal, DNB Internal Medicine, Post Graduate Diploma in Clinical Research and Business Development, Fellow DNB Nephrology, MRCP and ECFMG Certification. He has been closely associated with India Medical Association South Delhi Branch and Delhi Medical Association and has been organising continuing medical education programs on their behalf from time to time. Further he has been contributing medical articles for their newsletters as well. He is also associated with electronic media and TV for conduction and presentation of health programs. He has been associated with Medical Dialogues for last 3 years and contributing articles on regular basis.

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