Elevated non-HDL-C linked to higher mortality in patients undergoing peritoneal dialysis: Study

Written By : Medha Baranwal |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2021-07-15T09:45:53+05:30 | Updated On 15 July 2021 11:25 AM IST

China: An increased level of non-HDL-C raises the risk of cardiovascular (CV) mortality and all-cause mortality in patients undergoing peritoneal dialysis (PD), researchers report in a recent study in the Journal of Clinical Lipidology.

Peritoneal dialysis is a treatment for kidney failure that used the abdomen lining (called peritoneum), or, belly for filtering blood inside the body. Fengxian Huang, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China, and colleagues aimed to evaluate the association of non-HDL-C with cardiovascular and all-cause mortality in PD patients in a prospective cohort study.

The study included a total of 1,616 incident PD patients from a single PD center in South China. They were followed for a median of 47.6 months. Cox regression analysis was used to evaluate the independent association of non-HDL-C with CV and all-cause mortality.

Also Read: Peritoneal Dialysis is significantly improving patient outcomes: Experts

Upon analysis, the researchers found that:

· During the follow-up period, 31.4% patients died, of which 49.0% were due to CV events.

· Atherosclerotic CV mortality accounted for 59.8% of CV mortality.

· In multivariable models, for 1-SD increase in non-HDL-C level, the hazard ratios (HRs) for CV and all-cause mortality were 1.52 and 1.24 respectively.

· Non-HDL-C was positively associated with atherosclerotic CV mortality (HR, 1.29) but not associated with nonatherosclerotic CV mortality (HR, 0.79).

· The quartile analyses showed a similar pattern to the continuous variable analyses of non-HDL-C levels for CV and all-cause mortality but did not demonstrate statistical significance for atherosclerotic or nonatherosclerotic CV mortality.

Also Read: Higher-dose IV iron confers greater cardiovascular benefit in patients on dialysis: Study

"Our findings demonstrated that an elevated non-HDL-C level was independently associated with an increased risk of CV mortality, especially atherosclerotic CV mortality, and all-cause mortality in incident PD patients," concluded the authors.

Reference:

The study titled, "Non-high-density lipoprotein cholesterol and mortality among peritoneal dialysis patients," is published in the Journal of Clinical Lipidology.

DOI: https://www.lipidjournal.com/article/S1933-2874(21)00114-8/fulltext

Journal of Clinical Lipidologyperitoneal dialysisnon HDL C

Source : Journal of Clinical Lipidology

Medha Baranwal

MSc. Biotechnology

Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751