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  • Elobixibat effective...

Elobixibat effective for Constipation and Lipid Metabolism in CKD: Study

Dr. Shravani DaliWritten by Dr. Shravani Dali Published On 2022-03-28T09:00:59+05:30  |  Updated On 2022-03-28T09:01:26+05:30
Elobixibat  effective for Constipation and Lipid Metabolism in CKD: Study
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Elobixibat is effective for Constipation and Lipid Metabolism in Patients With Moderate to End-Stage Chronic Kidney DiseaseElobixibat is effective for Constipation and Lipid Metabolism in Patients With Moderate to End-Stage Chronic Kidney Diseaseaccording to a recent study published in the frontiers of medicine.

The aim of this study was to investigate the effects of elobixibat on constipation and lipid metabolism, and determine the factors associated with the effect of elobixibat on constipation in patients with moderate to end-stage chronic kidney disease (CKD).

Stool frequency and serum lipid parameters were retrospectively analyzed before and after 4 weeks of elobixibat administration in 42 patients (CKD stage G3, 6; stage G4, 9; stage G5, 9; stage G5D, 18). Relationships between the change in stool frequency after initiation of elobixibat and various clinical parameters were analyzed by using linear regression analysis.

Results:

Elobixibat increased stool frequency from 0.5 ± 0.4 per day to 1.1 ± 0.6 per day (p < 0.001) regardless of whether patients were undergoing dialysis, on concomitant laxatives, or were administered elobixibat before or after breakfast. Elobixibat reduced low-density lipoprotein cholesterol concentration (from 90.9 ± 37.2 mg/dL to 77.5 ± 34.8 mg/dL, p < 0.05) and increased high-density lipoprotein cholesterol concentration (from 44.9 ± 14.3 mg/dL to 57.0 ± 25.8 mg/dL, p < 0.05), but did not change triglyceride concentration. Adverse effects were observed in two patients (nausea and diarrhea). Only phosphate concentration was correlated with the change in stool frequency after initiation of elobixibat (standard coefficient = 0.321, p = 0.043).

The researchers concluded that Elobixibat improved constipation and lipid metabolism in patients with moderate to end-stage CKD, without serious adverse events.

Reference:

Effects of Elobixibat on Constipation and Lipid Metabolism in Patients With Moderate to End-Stage Chronic Kidney Disease by Momoko Matsuyama, et al. published in the frontiers in medicine.

https://www.frontiersin.org/articles/10.3389/fmed.2021.780127/full


Chronic constipation end-stage CKD Frontiers in Medicine Elobixibat Lipid Metabolism 
Source : frontiers in medicine
Dr. Shravani Dali
Dr. Shravani Dali

    BDS

    Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.

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