Long term exposure to air pollution increases risk of developing CKD

Chronic kidney disease (CKD) is a global disease burden related to high rates of incidence and mortality. It manifests as progressive and irretrievable nephron loss and decreased kidney regeneration capacity.Both genetic and environmental factors contribute to chronic kidney disease (CKD).

Air pollution contributes to significant numbers of premature deaths every year globally. The adverse effects of air pollution can be observed in not only in respiratory, circulatory systems but also in renal function

Studies in the past have suggested that exposure to air pollution is closely relevant to increased risk of CKD and progression of chronic kidney disease (CKD).

Researchers have found in a new study that among adults with normal kidney function, long term exposure to air pollution increases risk of developing was linked with higher risks of later developing chronic kidney later disease. Further compared with individuals with high genetic risk of developing kidney disease, those with high air pollution exposure and low genetic risk faced a higher risk of developing chronic kidney disease.

The results from the study will be presented at ASN Kidney Week 2022 November 3–November 6.

Investigators analyzed data from 350,994 participants without CKD at baseline in the UK Biobank. Exposure to higher concentrations of components of air pollution was linked with higher risks of developing chronic kidney disease (CKD). Compared with individuals with high genetic risk of developing chronic kidney disease (CKD), those with high air pollution exposure and low genetic risk faced a higher risk of developing chronic kidney disease (CKD).

"Long-term exposure to air pollution may increase the risk of CKD, especially in those with low genetic risk," the authors wrote.

Study: "Air pollution, genetic factors, and the risk of incident chronic kidney disease: a prospective study of polygenic risk score analysis in the UK Biobank"

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Long-term exposure to air pollution may increase kidney disease risk American Society of Nephrology. Meeting ASN Kidney Week 2022