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  • Long-Term Ozone...

Long-Term Ozone Exposure Linked to Increased Risk of Chronic Kidney Disease Mortality, reveals study

Written By : Dr Riya Dave |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2024-03-05T20:30:11+05:30  |  Updated On 6 March 2024 3:36 PM IST
Long-Term Ozone Exposure Linked to Increased Risk of Chronic Kidney Disease Mortality, reveals study
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Chronic kidney disease (CKD) is a significant public health concern worldwide, with mortality rates continuing to rise. While the adverse effects of environmental pollutants on respiratory and cardiovascular health are well-documented, the impact on renal outcomes remains unclear.

Ozone, a major component of air pollution, is known to induce oxidative stress and inflammation, which may contribute to the progression of CKD. A recent study aimed to investigate the association between long-term ozone (O3) exposure and mortality in individuals with CKD. This study was published in the journal of BMC Nephrology by Ejin Kim and colleagues.

A cohort of 61,073 participants was included in this study, with researchers employing Cox proportional hazards models to analyze the association between ozone exposure and the risk of end-stage renal disease (ESRD) and mortality. Ozone concentrations were calculated based on exposure one year before enrollment using inverse distance weighting (IDW) for interpolation. Models were adjusted for socioeconomic status and other measured pollutants.

The key findings of the study were:

• In both single and two-pollutant models, long-term ozone exposure was significantly associated with an increased risk of ESRD and all-cause mortality.

• The hazard ratios (HR) for ozone exposure varied depending on the assessment method, with HR values of 1.025 (95% CI: 1.014–1.035) at the district level and 1.04 (95% CI: 1.035–1.045) at the individual address level for ESRD risk.

• Similarly, HR values for all-cause mortality were 1.012 (95% CI: 1.008–1.017) at the district level and 1.04 (95% CI: 1.031–1.05) at the individual address level.

This study provides compelling evidence that long-term ambient ozone exposure increases the risk of end-stage renal disease and mortality in individuals with chronic kidney disease. The findings underscore the importance of implementing strategies to reduce ozone emissions, which would not only benefit public health but also contribute to environmental preservation. Efforts to mitigate ozone pollution are essential in safeguarding the health of vulnerable populations and promoting overall well-being.

Reference:

Kim, E., Huh, H., Mo, Y., Park, J. Y., Jung, J., Lee, H., Kim, S., Kim, D. K., Kim, Y. S., Lim, C. S., Lee, J. P., Kim, Y. C., & Kim, H. Long-term ozone exposure and mortality in patients with chronic kidney disease: a large cohort study. BMC Nephrology,2024;25(1). https://doi.org/10.1186/s12882-024-03500-6

BMC NephrologyOzonechronic kidney diseasemortalityend-stage renal diseaseair pollutionepidemiology
Source : BMC Nephrology
Dr Riya Dave
Dr Riya Dave

    Dr Riya Dave has completed dentistry from Gujarat University in 2022. She is a dentist and accomplished medical and scientific writer known for her commitment to bridging the gap between clinical expertise and accessible healthcare information. She has been actively involved in writing blogs related to health and wellness.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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