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  • Lumasiran shows...

Lumasiran shows efficacy in adults with reduced GFR and primary hyperoxaluria type 1

Written By : Dr. Kamal Kant Kohli Published On 2022-07-19T19:30:38+05:30  |  Updated On 19 July 2022 7:30 PM IST
Lumasiran shows efficacy in adults with reduced GFR and primary hyperoxaluria type 1
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Primary hyperoxaluria type 1 (PH1) is a rare, genetic disease characterized by excessive hepatic oxalate production that frequently causes end-stage kidney disease (ESKD). Lumasiran is an RNA interference therapeutic that is administered subcutaneously for the treatment of PH1.

Lumasiran has been shown to reduce oxalate levels in the urine and plasma of patients with PH1 who have relatively preserved kidney function. In the ILLUMINATE-C study, the efficacy and safety of lumasiran were evaluated in patients with PH1 and advanced kidney disease, including a cohort of patients on hemodialysis.

During the 6-month primary analysis period, lumasiran resulted in substantial reductions in plasma oxalate with acceptable safety in patients with PH1 complicated by advanced kidney disease. The most commonly reported lumasiran-related adverse events were injection-site reactions. These results were recently published in the American Journal of Kidney Diseases (AJKD).

Reference:

Mini Michael, Jaap W. Groothoff, Hadas Shasha-Lavsky, John C. Lieske, Yaacov Frishberg, Eva Simkova, Anne-Laure Sellier-Leclerc, Arnaud Devresse, Fitsum Guebre-Egziabher, Sevcan A. Bakkaloglu, Chebl Mourani, Rola Saqan, Richard Singer, Richard Willey, Bahru Habtemariam, John M. Gansner, Ishir Bhan, Tracy McGregor, Daniella Magen, Published:July 14, 2022

DOI:https://doi.org/10.1053/j.ajkd.2022.05.012



American Journal of Kidney DiseasesAJKDhyperoxaluriaGFRkidney diseasehemodialysisPH1
Source : American Journal of Kidney Diseases,AJKD
Dr. Kamal Kant Kohli
Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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