Relatively high proportion of diabetes patients experience rapid CKD progression: Study

Written By : Dr. Nandita Mohan |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2021-01-06T16:00:53+05:30 | Updated On 7 Jan 2021 1:52 PM IST

According to recent research, investigators have observed that a relatively high proportion of patients were observed with disease progression over a short period of time, highlighting the need for better identification of patients at risk of rapidly progressive CKD, as published in the Clinical Kidney Journal.

Chronic kidney disease (CKD), one of the most common complications of type 2 diabetes (T2D), is associated with poor health outcomes and high healthcare expenditures. As the CKD population increases, a better understanding of the prevalence and progression of CKD is critical. However, few contemporary studies have explored the progression of CKD relative to its onset in T2D patients using established markers derived from real-world care settings.

Hence, Csaba P Kovesdy and colleagues from the Department of Medicine, Division of Nephrology, University of Tennessee Health Science Center, Memphis, TN, USA conducted this population cohort study to assess the Chronic kidney disease progression among patients with type 2 diabetes identified in US administrative claims. A total of 65 731 and 23 035 patients with T2D contributed to the analysis of eGFR- and UACR-based CKD stage progression, respectively.

The authors included patients with T2D and laboratory evidence of CKD as indicated by the established estimated glomerular filtration rate (eGFR) and urine albumin: creatinine ratio (UACR) criteria. Disease progression was described as transitions across the eGFR- and UACR-based stages.

The observations were-

a. CKD worsening was observed in approximately 10–17% of patients over a median follow-up of 2 years.

b. Approximately one-third of patients experienced an increase in eGFR values or a decrease in UACR values during follow-up.

Therefore, the authors concluded that "A relatively high proportion of patients were observed with disease progression over a short period of time, highlighting the need for better identification of patients at risk of rapidly progressive CKD. Future studies are needed to determine the clinical characteristics of these patients to inform earlier diagnostic and therapeutic interventions aimed at slowing disease progression."

#DiabetesChronic kidney diseaseClinical Kidney Journal.type 2 diabetesdisease progression

Source : Clinical Kidney Journal

Dr. Nandita Mohan

Dr. Nandita Mohan is a practicing pediatric dentist with more than 5 years of clinical work experience. Along with this, she is equally interested in keeping herself up to date about the latest developments in the field of medicine and dentistry which is the driving force for her to be in association with Medical Dialogues. She also has her name attached with many publications; both national and international. She has pursued her BDS from Rajiv Gandhi University of Health Sciences, Bangalore and later went to enter her dream specialty (MDS) in the Department of Pedodontics and Preventive Dentistry from Pt. B.D. Sharma University of Health Sciences. Through all the years of experience, her core interest in learning something new has never stopped. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751