Medical Dialogues
  • Dermatology
Login Register
This site is intended for healthcare professionals only
Login Register
  • MD Brand Connect
  • Vaccine Hub
  • MDTV
    • Breaking News
    • Medical News Today
    • Health News Today
    • Latest
    • Journal Club
    • Medico Legal Update
    • Latest Webinars
    • MD Shorts
    • Health Dialogues
  • Fact Check
  • Health Dialogues
Medical Dialogues
  • Medical News & Guidelines
      • Anesthesiology
      • Cardiology and CTVS
      • Critical Care
      • Dentistry
      • Dermatology
      • Diabetes and Endocrinology
      • ENT
      • Gastroenterology
      • Medicine
      • Nephrology
      • Neurology
      • Obstretics-Gynaecology
      • Oncology
      • Ophthalmology
      • Orthopaedics
      • Pediatrics-Neonatology
      • Psychiatry
      • Pulmonology
      • Radiology
      • Surgery
      • Urology
      • Laboratory Medicine
      • Diet
      • Nursing
      • Paramedical
      • Physiotherapy
  • Health news
      • Doctor News
      • Government Policies
      • Hospital & Diagnostics
      • International Health News
      • Medical Organization News
      • Medico Legal News
      • NBE News
      • NMC News
  • Fact Check
      • Bone Health Fact Check
      • Brain Health Fact Check
      • Cancer Related Fact Check
      • Child Care Fact Check
      • Dental and oral health fact check
      • Diabetes and metabolic health fact check
      • Diet and Nutrition Fact Check
      • Eye and ENT Care Fact Check
      • Fitness fact check
      • Gut health fact check
      • Heart health fact check
      • Kidney health fact check
      • Medical education fact check
      • Men's health fact check
      • Respiratory fact check
      • Skin and hair care fact check
      • Vaccine and Immunization fact check
      • Women's health fact check
  • AYUSH
    • Ayurveda
    • Homeopathy
    • Siddha
    • Unani
    • Yoga
  • State News
      • Andaman and Nicobar Islands
      • Andhra Pradesh
      • Arunachal Pradesh
      • Assam
      • Bihar
      • Chandigarh
      • Chattisgarh
      • Dadra and Nagar Haveli
      • Daman and Diu
      • Delhi
      • Goa
      • Gujarat
      • Haryana
      • Himachal Pradesh
      • Jammu & Kashmir
      • Jharkhand
      • Karnataka
      • Kerala
      • Ladakh
      • Lakshadweep
      • Madhya Pradesh
      • Maharashtra
      • Manipur
      • Meghalaya
      • Mizoram
      • Nagaland
      • Odisha
      • Puducherry
      • Punjab
      • Rajasthan
      • Sikkim
      • Tamil Nadu
      • Telangana
      • Tripura
      • Uttar Pradesh
      • Uttrakhand
      • West Bengal
  • Medical Education
      • Ayush Education News
      • Dentistry Education News
      • Medical Admission News
      • Medical Colleges News
      • Medical Courses News
      • Medical Universities News
      • Nursing education News
      • Paramedical Education News
      • Study Abroad
  • Industry
      • Health Investment News
      • Health Startup News
      • Medical Devices News
      • Pharma News
      • Pharmacy Education News
      • Industry Perspective
  • MDTV
      • Health Dialogues MDTV
      • Health News today MDTV
      • Latest Videos MDTV
      • Latest Webinars MDTV
      • MD shorts MDTV
      • Medical News Today MDTV
      • Medico Legal Update MDTV
      • Top Videos MDTV
      • Health Perspectives MDTV
      • Journal Club MDTV
      • Medical Dialogues Show
This site is intended for healthcare professionals only
LoginRegister
Medical Dialogues
LoginRegister
  • Home
  • Medical news & Guidelines
    • Anesthesiology
    • Cardiology and CTVS
    • Critical Care
    • Dentistry
    • Dermatology
    • Diabetes and Endocrinology
    • ENT
    • Gastroenterology
    • Medicine
    • Nephrology
    • Neurology
    • Obstretics-Gynaecology
    • Oncology
    • Ophthalmology
    • Orthopaedics
    • Pediatrics-Neonatology
    • Psychiatry
    • Pulmonology
    • Radiology
    • Surgery
    • Urology
    • Laboratory Medicine
    • Diet
    • Nursing
    • Paramedical
    • Physiotherapy
  • Health news
    • Doctor News
    • Government Policies
    • Hospital & Diagnostics
    • International Health News
    • Medical Organization News
    • Medico Legal News
    • NBE News
    • NMC News
  • Fact Check
    • Bone Health Fact Check
    • Brain Health Fact Check
    • Cancer Related Fact Check
    • Child Care Fact Check
    • Dental and oral health fact check
    • Diabetes and metabolic health fact check
    • Diet and Nutrition Fact Check
    • Eye and ENT Care Fact Check
    • Fitness fact check
    • Gut health fact check
    • Heart health fact check
    • Kidney health fact check
    • Medical education fact check
    • Men's health fact check
    • Respiratory fact check
    • Skin and hair care fact check
    • Vaccine and Immunization fact check
    • Women's health fact check
  • AYUSH
    • Ayurveda
      • Ayurveda Giuidelines
      • Ayurveda News
    • Homeopathy
      • Homeopathy Guidelines
      • Homeopathy News
    • Siddha
      • Siddha Guidelines
      • Siddha News
    • Unani
      • Unani Guidelines
      • Unani News
    • Yoga
      • Yoga Guidelines
      • Yoga News
  • State News
    • Andaman and Nicobar Islands
    • Andhra Pradesh
    • Arunachal Pradesh
    • Assam
    • Bihar
    • Chandigarh
    • Chattisgarh
    • Dadra and Nagar Haveli
    • Daman and Diu
    • Delhi
    • Goa
    • Gujarat
    • Haryana
    • Himachal Pradesh
    • Jammu & Kashmir
    • Jharkhand
    • Karnataka
    • Kerala
    • Ladakh
    • Lakshadweep
    • Madhya Pradesh
    • Maharashtra
    • Manipur
    • Meghalaya
    • Mizoram
    • Nagaland
    • Odisha
    • Puducherry
    • Punjab
    • Rajasthan
    • Sikkim
    • Tamil Nadu
    • Telangana
    • Tripura
    • Uttar Pradesh
    • Uttrakhand
    • West Bengal
  • Medical Education
    • Ayush Education News
    • Dentistry Education News
    • Medical Admission News
    • Medical Colleges News
    • Medical Courses News
    • Medical Universities News
    • Nursing education News
    • Paramedical Education News
    • Study Abroad
  • Industry
    • Health Investment News
    • Health Startup News
    • Medical Devices News
    • Pharma News
      • CDSCO (Central Drugs Standard Control Organisation) News
    • Pharmacy Education News
    • Industry Perspective
  • Home
  • Nephrology
  • Nephrology News
  • Study: Mycophenolate...

Study: Mycophenolate Mofetil and Steroid as Alternative for Idiopathic Membranous Nephropathy Treatment

Nidhi SrivastavaWritten by Nidhi Srivastava Published On 2024-08-07T21:30:56+05:30  |  Updated On 7 Aug 2024 9:31 PM IST
Study: Mycophenolate Mofetil and Steroid as Alternative for Idiopathic Membranous Nephropathy Treatment
  • facebook
  • twitter
  • linkedin
  • whatsapp
  • Telegram
  • Email

India: An article published in The Journal of the Association of Physicians of India found that both mycophenolate mofetil combined with steroids and the modified Ponticelli regimen had similar tolerability and effectiveness. However, the use of MMF was associated with the advantage of reduced steroid exposure.

Membranous nephropathy is responsible for more than 25% of nephrotic syndrome cases in adults, with an overall incidence of 1.2 per 100,000 annually. The peak occurrence is in the fourth and fifth decades of life. About three-quarters of these patients have idiopathic membranous nephropathy, characterized by varying outcomes: one-third experience spontaneous remission, another third continue with persistent proteinuria, and the remaining third advance to severe renal failure.

The modified Ponticelli regimen is commonly used as a first-line therapy for patients with idiopathic membranous nephropathy, though it is known for having a less favorable safety profile. Despite the Kidney Disease Improving Global Outcomes guidelines not recommending the combination of mycophenolate mofetil and steroids, this alternative treatment can be considered due to its higher tolerability and steroid-sparing benefits.

With this reference, Manjuri Sharma, Professor and Head of the Department of Nephrology at Gauhati Medical College and Hospital in Guwahati et. al. conducted a study comparing the safety and effectiveness of the mycophenolate mofetil + steroid regimen with the modified Ponticelli regimen in patients with idiopathic membranous nephropathy.

A randomized, open-label study was conducted involving patients diagnosed with adult-onset nephrotic syndrome and biopsy-confirmed idiopathic membranous nephropathy. Forty-two participants were divided into two treatment groups: mycophenolate mofetil + steroid group (mycophenolate mofetil 1 gram twice daily combined with oral prednisolone 0.5 mg/kg/day; n = 21) and the modified Ponticelli regimen group (which received methylprednisolone 1 gram intravenously for 3 days, followed by alternating monthly cycles of oral prednisolone 0.5 mg/kg/day for the subsequent 27 days, and cyclophosphamide 2 mg/kg/day for 6 months; n = 21). The primary outcome assessed was the change in the urinary protein-to-creatinine ratio.

The key findings of the study were as follows:

  • At six months, both groups showed a significant increase in serum albumin levels and estimated glomerular filtration rate.
  • Both groups demonstrated a notable decrease in 24-hour proteinuria, with the mycophenolate mofetil + steroid group and the modified Ponticelli regimen group
  • Both groups also exhibited a significant decrease in the urinary protein-to-creatinine ratio.
  • The groups did not show significant differences in these parameters at any of the monthly follow-up visits.
  • The composite remission rates were 61.91% for the mycophenolate mofetil + steroid group and 71.43% for the modified Ponticelli regimen group, with no significant difference between the groups.

Researchers concluded that 62% of patients with idiopathic membranous nephropathy responded positively to first-line therapy with mycophenolate mofetil + steroids. The mycophenolate mofetil + steroids treatment demonstrated similar tolerability and effectiveness compared to modified Ponticelli regimen, with the added benefit of reduced steroid exposure.

Reference

Sharma M, Roy A, Doley PK, et al. Mycophenolate Mofetil with Steroid, a Reasonable Alternative to Current First-line Therapy, for Idiopathic Membranous Nephropathy in Resource-constrained Settings: A Randomized, Open-label Study. J Assoc Physicians India 2024;72(6):15-19.

Mycophenolate MofetilIdiopathic Membranous Nephropathynephropathykidneykidney disease
Nidhi Srivastava
Nidhi Srivastava

    Nidhi Srivastava is a dietician. She holds a post-graduate degree in Nutrition and Dietetics from MRIIRS. With a profound passion for utilizing nutrition and lifestyle modifications to manage diseases, she is dedicated to advancing the field through rigorous research and fact-checking. Her expertise lies in evidence-based practice, ensuring the highest standards of dietary health and wellness.

    Show Full Article
    Next Story

    Editorial

    Real-World Case study: Darbepoetin Alfa for Chemotherapy-Induced Anemia in Metastatic Breast Cancer - Dr Aditya Murali

    Real-World Case study: Darbepoetin Alfa for Chemotherapy-Induced Anemia in Metastatic Breast Cancer...

    Aspirin in Primary Prevention- When to Consider?

    Aspirin in Primary Prevention- When to Consider?

    Featured image representing medico legal

    What's the Role of Expert Opinion in Medical Negligence?

    7- Point Discharge Protocol for AECOPD: Time to Inculcate in Practice

    7- Point Discharge Protocol for AECOPD: Time to Inculcate in Practice

    Aspirin Use in Women Aged 40-50 with Diabetes and Hypertension: Identifying the Ideal Candidates

    Aspirin Use in Women Aged 40-50 with Diabetes and Hypertension: Identifying the Ideal Candidates

    View All

    Journal Club Today

    Real-World Case study: Darbepoetin Alfa for Chemotherapy-Induced Anemia in Metastatic Breast Cancer - Dr Aditya Murali

    Real-World Case study: Darbepoetin Alfa for Chemotherapy-Induced Anemia in Metastatic Breast Cancer...

    View All

    Health News Today

    Health Bulletin 09/ May/ 2025

    Health Bulletin 09/ May/ 2025

    View All
    © 2022 All Rights Reserved.
    Powered By: Hocalwire
    X
    We use cookies for analytics, advertising and to improve our site. You agree to our use of cookies by continuing to use our site. To know more, see our Cookie Policy and Cookie Settings.Ok