Supplementing antibiotics with D-mannose enhances UTI treatment, says study

Written By : Medha Baranwal |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-04-19T09:00:59+05:30 | Updated On 19 April 2022 9:01 AM IST

Finland: Antibiotics are likely to remain the first choice for the treatment of acute urinary tract infections (UTIs), according to findings from a narrative review published in Nutrition Journal. Treatment success may be increased by supplementing antibiotics with D-mannose. However, for prophylaxis in reducing UTI recurrence, D-mannose appears to have great potential with minimal side effects.

Urinary tract infections (UTIs) are one of the most prevalent bacterial diseases worldwide."A non-antibiotic alternative would be most beneficial for individuals in need of repetitive antibiotic treatments, going through urogenital procedures, or women with a changed bacterial environment in the urogenital area," Arthur C. Ouwehand, Health & Biosciences, International Flavors & Fragrances, Kantvik, Finland, and colleagues wrote in their study. "Due to increasing antibiotic resistance among UTI pathogens, the burden caused by UTIs is expected to increase resulting in high demand for alternative options."

D-mannose is commonly marketed as a dietary supplement for reducing the risk for UTIs. It is a monosaccharide naturally found in fruits. Investigations have suggested that supplemented D-mannose be a promising alternative or complementary remedy, especially as a prophylaxis for recurrent UTIs. D-mannose potentially inhibits Escherichia coli (the main causative organism of UTIs) from attaching to urothelium and causing infection, when excreted in urine>

In the review, Dr. Ouwehand and the team aimed to examine the current evidence on the role of D-mannose against UTI. They provided an overview of UTIs, E. coli pathogenesis, and D-mannose and outline the existing clinical evidence of D-mannose in reducing UTI risk and its recurrence. Furthermore, the potential effect mechanisms of D-mannose against uropathogenic E.coli were also discussed.

"The overall picture of preclinical and clinical studies with D-mannose in the management of UTI is favorable, as discussed here and in a recent narrative review by De Nunzio et al, the authors concluded. "D-mannose has also been shown to be relatively safe and well-tolerated."

Reference:

Ala-Jaakkola, R., Laitila, A., Ouwehand, A.C. et al. Role of D-mannose in urinary tract infections – a narrative review. Nutr J 21, 18 (2022). https://doi.org/10.1186/s12937-022-00769-x

Nutrition Journalurinary tract infectionsUTIsD-mannose

Source : Nutrition Journal

Medha Baranwal

MSc. Biotechnology

Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751