TyG Index novel Prognostic Indicator in CKD Patients, reveals research

Written By : Dr. Shravani Dali |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2025-02-14T06:45:59+05:30 | Updated On 14 Feb 2025 11:43 AM IST

Researchers have found in a new study that a high TyG index predicts poor clinical outcomes and may serve as a novel prognostic indicator in CKD patients. However, further studies are needed to validate these findings.

A study was done to identify the relationship of triglyceride-glucose (TyG) index with clinical outcomes in chronic kidney disease (CKD) patients based on current available evidence. PubMed, EMBASE, Web of Science and CNKI databases were searched up to August 31, 2024.

Primary outcome was the all-cause mortality. Secondary outcomes included the coronary artery disease (CAD) mortality, CKD progression, risk of severe coronary artery stenosis (SCAS), major adverse cardiovascular event (MACE), coronary artery calcification (CAC) progression, end-stage renal disease (ESRD), and nonalcoholic fatty liver disease (NAFLD). The hazard ratio (HR) and odds ratio (OR) with 95% confidence interval (CI) were combined to assess the predictive role of TyG index for above clinical outcomes among CKD patients. All statistical analysis was performed by STATA 15.0 version. Results: Twelve studies with 26,530 cases were included.

Pooled results indicated that elevated TyG index was significantly related to increased risk for all-cause mortality (HR = 1.22, 95% CI: 1.13–1.31, P<0.001). Besides, high TyG index was also associated with the CAD mortality (HR = 1.19, 95% CI: 1.04–1.36, P = 0.011), occurrence of CKD progression (HR = 1.52, 95% CI: 1.36–1.70, P<0.001), SCAS (OR = 1.79, 95% CI: 1.13–2.83, P = 0.013), MACE (OR = 1.68, 95% CI: 1.11–2.54, P = 0.014), CAC progression (OR = 1.55, 95% CI: 1.06–1.76, P = 0.02), CAD (OR = 2.865, 95% CI: 1.681–4.885, P<0.001), ESRD (OR = 1.49, 95% CI: 1.12–1.99, P = 0.006) and NAFLD (OR = 4.903, 95% CI: 3.046–7.893, P<0.001). High TyG index predicts poor clinical outcomes and might serve as a novel prognostic indicator among CKD patients. However, more studies are still needed to verify above findings.

Reference:

Tuo, J., Li, Z. & Xie, L. Association between triglyceride-glucose index and clinical outcomes among patients with chronic kidney disease: a meta-analysis. BMC Nephrol 26, 61 (2025). https://doi.org/10.1186/s12882-025-03984-w

TyG IndexnovelprognosticIndicatorCKDPatientsrevealsresearch

Source : BMC Nephrology

Dr. Shravani Dali

Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751