TyG Index Potential Marker for evaluating kidney function and Diabetic Kidney Disease: Study
A new study published in the Journal of Diabetes & Metabolic Disorders found TyG Index as an indicator for diabetic kidney disease (DKD) in individuals with type 2 diabetes (T2D), highlighting its potential clinical use in evaluating renal function deterioration.
Diabetes continues to have an unacceptably high incidence worldwide, with a steady upward trend. The mortality of diabetes patients and the frequency of cardiovascular events are significantly impacted by end-stage renal disease (ESRD). A higher percentage of people with type 2 diabetes experience DKD than those with type 1 diabetes.
Numerous cardiovascular conditions, including atherosclerosis, acute coronary syndrome, and heart failure, have been discovered to be strongly correlated with the TyG index, a new measure generated from triglycerides (TG) and fasting plasma glucose (FPG). TyG Index is a straightforward indicator of insulin resistance. It is unknown how it affects the development of diabetic kidney disease (DKD) in people with type 2 diabetes. Thus, this study examined the relationship between the TyG index and the advancement of DKD in T2D.
This study included 428 T2D patients with and without DKD. According to the Kidney Disease Improving Global Outcomes (KDIGO) criteria, the progression of DKD was determined. The TyG index was used to separate patient demographic data into quartiles. The relationship between the TyG Index and metabolic markers was examined using multiple regression.
According to the findings, 257 individuals (60.0%) experienced DKD. The TyG index was considerably higher in the DKD group than in the non-DKD group (9.9 ± 0.7 vs. 9.4 ± 0.6, P < 0.001). Age, systolic blood pressure, glycated hemoglobin, triglycerides, urea, total cholesterol, uric acid, LDH, creatinine, albumin creatinine ratio, and TyG index (P < 0.05 for each), glycated hemoglobin, triglycerides, and eGFR were all lower in the DKD group.
An elevated TyG index was identified as an independent risk factor for DKD. Overall, the TyG Index may be an indication of DKD in T2D patients. This data confirms the clinical value of TyG index in evaluating renal function worsening in DKD patients.
Source:
Siddiqui, K., Nawaz, S. S., George, T. P., David, S. K., Alfadda, A. A., & Rafiullah, M. (2025). Association of triglyceride-glucose index with diabetic kidney disease in patients with type 2 diabetes. Journal of Diabetes and Metabolic Disorders, 24(2), 171. https://doi.org/10.1007/s40200-025-01680-y
