Vitamin D might reduce risk of nephropathy in diabetes patients

Written By : Dr. Shravani Dali |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2023-06-30T20:00:16+05:30 | Updated On 1 July 2023 5:34 PM IST

Vitamin D is associated with reduced risk of diabetic nephropathy in diabetics suggests a new study published in the BMC Nephrology. However, whether this association is causative is uncertain.

Diabetic nephropathy (DN) is the leading cause of end-stage renal disease (ESRD) and is associated with a high risk of cardiovascular disease. Proteinuria, hypertension, and gradual declines in kidney function are the clinical manifestations

The researchers used two-sample Mendelian randomization to examine the causal influence of vitamin D on diabetic nephropathy in 7,751 individuals with type I diabetes-related nephropathy (T1DN) and 9,933 individuals with type II diabetes-related nephropathy (T2DN). Meanwhile, we repeated some previous studies on the influence of KIM-1 (kidney injury molecule 1) and body mass index (BMI) on DN. Additionally, to test the validity of the instruments variable for vitamin D, we conducted two negative controls Mendelian randomization (MR) on breast and prostate cancer, and a positive control MR on multiple sclerosis.

Results

Results of the MR analysis showed that there was no causal association between 25(OH)D with the early/later stage of T1DN (early: OR = 0.903, 95%CI: 0.229 to 3.555; later: OR = 1.213, 95%CI: 0.367 to 4.010) and T2DN (early: OR = 0.588, 95%CI: 0.182 to 1.904; later: OR = 0.904, 95%CI: 0.376 to 2.173), nor with the kidney function of patients with diabetes mellitus: eGFRcyea (creatinine-based estimated GFR) (Beta = 0.007, 95%CI: -0.355 to 0.369)) or UACR (urinary albumin creatinine ratio) (Beta = 0.186, 95%CI: -0.961 to 1.333)).

The researchers found no evidence that Vitamin D was causally associated with DN or kidney function in diabetic patients.

Reference:

He, M., Yang, T., Zhou, P. et al. A Mendelian randomization study on causal effects of 25(OH) vitamin D levels on diabetic nephropathy. BMC Nephrol 24, 192 (2023). https://doi.org/10.1186/s12882-023-03186-2

Keywords:

He, M., Yang, T., Zhou, P, Mendelian, randomization, study, causal, effects, 25(OH), vitamin, D, levels, diabetic, nephropathy, BMC Nephrology

BMC NephrologyVitamin DcausallyassociatedDNkidneyfunctiondiabetic patients

Source : BMC Nephrology

Dr. Shravani Dali

Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751