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Vitamin D supplements may not improve kidney function in people with prediabetes: Study
![Vitamin D supplements may not improve kidney function in people with prediabetes: Study Vitamin D supplements may not improve kidney function in people with prediabetes: Study](https://medicaldialogues.in/h-upload/2020/02/27/750x450_124770-vitamin-d.webp)
The benefits of vitamin D might be greater in people with low blood vitamin D levels and/or reduced kidney function with prediabetes.
USA: A recent study published in CJASN did not show the benefit of vitamin D supplements on kidney function in people with prediabetes.
The trial by Sun H. Kim, MD, MS (Stanford University School of Medicine), and colleagues examined the potential of vitamin D supplementation for protecting the kidney health of people with pre-diabetes.
In the general population, low blood vitamin D levels have been associated with higher risks of various diseases, including type 2 diabetes and kidney disease. Sun H. Kim, MD, MS (Stanford University School of Medicine) and her colleagues conducted a secondary analysis of the Vitamin D and type 2 diabetes (D2d) study to evaluate the effects of vitamin D supplementation on kidney health in individuals with pre-diabetes, a condition that increases the risk for type 2 diabetes, which in turn is the leading cause of kidney disease.
The study randomized 2,423 adults with overweight/obesity and pre-diabetes to vitamin D3 4000 IU per day or placebo, for a median treatment duration of 2.9 years. "The D2d study is unique because we recruited individuals with high-risk pre-diabetes, having 2-out-of-3 abnormal glucose values, and we recruited more than 2,000 participants, representing the largest vitamin D diabetes prevention trial to date," said Dr. Kim.
During the trial, there were 28 cases of kidney function worsening in the vitamin D group and 30 in the placebo group, and the average change in kidney function during follow-up was similar in both groups. "Our results did not show a benefit of vitamin D supplements on kidney function. About 43% of the study population was taking outside-of-study vitamin D, up to 1000 IU daily, at study entry, though. Among those who were not taking any vitamin D on their own, there was a suggestion for vitamin D lowering the amount of urine protein over time, which means that it could have a beneficial effect on kidney health. Additional studies are needed to look into this further."
Dr. Kim added that vitamin D supplementation is popular, and it's difficult for clinical trials of vitamin D supplementation to show a benefit if the population studied is not vitamin D deficient. "The majority of the study population had sufficient blood vitamin D levels and normal kidney function," she said. "Benefits of vitamin D might be greater in people with low blood vitamin D levels and/or reduced kidney function."
Reference:
The study titled, "Effect of Vitamin D Supplementation on Kidney Function in Adults with Prediabetes," is published in the Clinical Journal of the American Society of Nephrology (CJASN).
Hina Zahid Joined Medical Dialogue in 2017 with a passion to work as a Reporter. She coordinates with various national and international journals and association and covers all the stories related to Medical guidelines, Medical Journals, rare medical surgeries as well as all the updates in the medical field. Email:Â editorial@medicaldialogues.in. Contact no. 011-43720751
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: editorial@medicaldialogues.in. Contact no. 011-43720751