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Brain's right hemisphere can compensate for speech loss after left hemisphere stroke in infants, study

Written By : Dr. Kamal Kant Kohli Published On 2023-03-25T09:15:32+05:30  |  Updated On 25 March 2023 2:55 PM IST
Brains right hemisphere can compensate for speech loss after left hemisphere stroke in infants, study
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Washington, DC: Researchers at Georgetown University Medical Center addressing the question, "what happens when one of the hemispheres is injured at birth?" found that for children who had a major stroke to the left hemisphere of their brain within days of their birth, the infant's brain was 'plastic enough' for the right hemisphere to acquire the language abilities ordinarily handled by the left side while also maintaining its own language abilities as well. The findings appear in PNAS.

The left hemisphere of the brain is normally responsible for sentence processing (understanding words and sentences as we listen to speech). The right hemisphere of the brain is normally responsible for processing the emotion of the voice-is it happy or sad, angry or calm.

The participants in this study developed normally during pregnancy. But around birth, they had a significant stroke, one that would have debilitating outcomes in adults. In infants, a stroke is much rarer but does happen in roughly one out of every four thousand births.

The researchers studied perinatal arterial ischemic stroke, a type of brain injury occurring around the time of birth in which blood flow is cut off to a part of the brain by a blood clot. The same type of stroke occurs much more commonly in adults. Previous studies of brain injury in infants have included several types of brain injury, but the focus in this study on a specific type of injury enabled the authors to find more consistent effects than in previous work.

"Our most important conclusion is that plasticity in the brain, specifically the ability to reorganize language to the opposite side of the brain, is definitely possible early in life," says Elissa Newport, Ph.D., director of the Center for Brain Plasticity and Recovery at Georgetown Medical Center, professor in the departments of Neurology and Rehabilitation Medicine and first author of this study.

"However, this early plasticity for language is restricted to one brain region. The brain is not able to reorganize injured functions just anywhere as more dramatic reorganization is not possible even in early life. This gives us great insights into the regions we might be able to focus on for potential breakthroughs in developing techniques for recovery in adults as well."

The investigators recruited people from across the United States who all had medium to large strokes to the cortex region of their left hemisphere around the time of birth. To assess long-term outcomes in their language abilities, participants were given language tests at 9 to 26 years of age and were compared to their close-in-age healthy siblings. They were also scanned in an MRI to reveal which brain areas were involved in sentence comprehension.

The participants and their healthy siblings all completed the language tasks almost perfectly. The major difference was that the stroke participants processed sentences on the right side of the brain while their siblings processed sentences on the left side. The stroke participants showed a very consistent pattern of language activation in the right hemisphere, regardless of the extent or location of damage from the stroke to the left hemisphere. Only one of the 15 participants, who had the smallest stroke, did not show clear right hemisphere dominant activation.

"It is also notable that many years after their strokes our participants are all such highly functioning adults. Some are honor students and others are working toward or have gotten their master's degrees," says Newport. "Their achievements are remarkable, especially since some of their parents had been told when they were born that their strokes would produce life-long impairments."

In future studies the researchers hope to gain a better understanding of why the left hemisphere routinely becomes dominant in healthy brains but consistently loses out to the right hemisphere when there is a significant left-hemisphere stroke.

An additional question of special interest-and clinical importance-is why left hemisphere language can successfully reorganize to the right hemisphere if injuries occur very early in life but not later. Research on stroke recovery and sentence processing in adults suggests that plasticity narrows with age, something that Newport hopes to study as it could be of great benefit, and potential therapeutic interest, to adult stroke survivors.

Reference:

Barbara Landau, Peter E. Turkeltaub, Catherine E. Chambers, Kelly C. Martin, Rebecca Rennert, Margot Giannetti, Alexander W. Dromerick, Rebecca N. Ichord, Jessica L. Carpenter, William D. Gaillard, https://doi.org/10.1073/pnas.2207293119

StrokeBrainLeft hemisphereBrain injuryBrain stokeMRIStroke survivors
Source : PNAS
Dr. Kamal Kant Kohli
Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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