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Epidural stimulation of the spinal cord instantly improves arm and hand movement after stroke: Study

Written By : Dr. Kamal Kant Kohli Published On 2023-03-03T09:45:49+05:30  |  Updated On 3 March 2023 12:41 PM IST
Epidural stimulation of the spinal cord instantly improves arm and hand movement after stroke: Study
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USA: Spinal cord stimulation can aid upper-limb recovery after stroke, a recent study published in Nature Medicine has shown.

Researchers from the University of Pittsburgh and Carnegie Mellon University reported that a neurotechnology that stimulates the spinal cord instantly improves hand and arm mobility, enabling people (affected by stroke) to conduct their normal daily activities more easily.

A pair of thin metal electrodes resembling strands of spaghetti implanted along the neck engages intact neural circuits, allowing stroke patients to fully open and close their fists, lift their arm above their head or use a fork and knife to cut a piece of steak for the first time in years.

“We discovered that electrical stimulation of specific spinal cord regions enables patients to move their arm in ways they cannot do without it. Perhaps even more interesting, we found that after a few weeks of use, some of these improvements endure when the stimulation is switched off, indicating exciting avenues for the future of stroke therapies,” said corresponding and co-senior author Marco Capogrosso, Ph.D., assistant professor of neurological surgery at Pitt. “Thanks to years of preclinical research building up to this point, we have developed a practical, easy-to-use stimulation protocol adapting existing FDA-approved clinical technologies that could be easily translated to the hospital and quickly moved from the lab to the clinic.”

When it comes to strokes, doctors predict a grim future: Globally, every fourth adult over 25 will suffer a stroke in their lifetime, and 75% of those people will have lasting deficits in motor control of their arm and hand, severely limiting their physical autonomy.

Currently, no treatments are effective for treating paralysis in the so-called chronic stage of stroke, which begins approximately six months after the stroke incident. The new technology, researchers say, has the potential to offer hope for people living with impairments that would otherwise be considered permanent.

“Creating effective neurorehabilitation solutions for people affected by movement impairment after stroke is becoming ever more urgent,” said senior co-author Elvira Pirondini, Ph.D., assistant professor of physical medicine and rehabilitation at Pitt. “Even mild deficits resulting from a stroke can isolate people from social and professional lives and become very debilitating, with motor impairments in the arm and hand being especially taxing and impeding simple daily activities, such as writing, eating and getting dressed.”

Spinal cord stimulation technology uses a set of electrodes placed on the surface of the spinal cord to deliver pulses of electricity that activate nerve cells inside the spinal cord. This technology is already being used to treat high-grade, persistent pain. Additionally, multiple research groups around the world have shown that spinal cord stimulation can be used to restore movement to the legs after spinal cord injury.

But the unique dexterity of the human hand, combined with the wide range of motion of the arm at the shoulder and the complexity of the neural signals controlling the arm and hand, add a significantly higher set of challenges.

Following years of extensive preclinical studies involving computer modeling and animal testing in macaque monkeys with partial arm paralysis, researchers were cleared to test this optimized therapy in humans.

“The sensory nerves from the arm and hand send signals to motor neurons in the spinal cord that control the muscles of the limb,” said co-senior author Douglas Weber, Ph.D., professor of mechanical engineering at the Neuroscience Institute at Carnegie Mellon University. “By stimulating these sensory nerves, we can amplify the activity of muscles weakened by a stroke. Importantly, the patient retains full control of their movements: The stimulation is assistive and strengthens muscle activation only when patients are trying to move.”

In a series of tests adapted to individual patients, stimulation enabled participants to perform tasks of different complexity, from moving a hollow metal cylinder to grasping common household objects, such as a can of soup and opening a lock. Clinical assessments showed that stimulation targeting cervical nerve roots immediately improves strength, range of movement and function of the arm and hand.

Unexpectedly, the effects of stimulation seem to be longer-lasting than scientists originally thought and persisted even after the device was removed, suggesting it could be used both as an assistive and a restorative method for upper limb recovery. Indeed, the immediate effects of the stimulation enable the administration of intense physical training that, in turn, could lead to even stronger long-term improvements in the absence of the stimulation.

Moving forward, researchers continue to enrol additional trial participants to understand which stroke patients can benefit most from this therapy and how to optimize stimulation protocols for different severity levels.

Reference:

Powell, M.P., Verma, N., Sorensen, E. et al. Epidural stimulation of the cervical spinal cord for post-stroke upper-limb paresis. Nat Med (2023). https://doi.org/10.1038/s41591-022-02202-6

Nature MedicineSpinal cordstrokeneural circuitsspinal cord injurycervical nerveparalysis
Source : Nature Medicine
Dr. Kamal Kant Kohli
Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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