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  • Harmful Body Fat Not...

Harmful Body Fat Not Only Increases Waistline, but Also Risk of Dementia

Written By : Hina Zahid |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2021-07-28T09:00:17+05:30  |  Updated On 28 July 2021 11:47 AM IST
Harmful Body Fat Not Only Increases Waistline, but Also Risk of Dementia
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It's the global epidemic that affects two in every five adults, but as obesity continues to expand waistlines worldwide, researchers at the University of South Australia are warning that harmful body fat can also increase the risk of dementia and stroke.

Examining grey brain matter of about 28,000 people, the world first research showed that increased body fat incrementally leads to increased atrophy of grey matter in the brain and consequently higher risk of declining brain health.

Grey matter is an essential part of the brain responsible for execution control, muscular and sensory activity as well as learning, attention, and memory.

Obesity is a major issue worldwide, with numbers nearly tripling since 1975. Data from the World Health Organization shows that more than 1.9 billion adults are overweight, with 650 million being obese. More than 340 million children (aged 5-19) are overweight or obese, with 39 million children under the age of five also falling into this category.

Lead researcher, UniSA's Dr Anwar Mulugeta, says the findings add to the growing issues associated with being overweight or obese.

"Obesity is a genetically complex condition characterised by the excessive body fat," Dr Mulugeta says.

"Commonly linked to cardiovascular disease, type 2 diabetes, and chronic inflammation (a marker of dementia), obesity currently costs Australia's economy about $8.6 billion dollars each year.

"While the disease burden of obesity has increased over the past five decades, the complex nature of the disease means that not all obese individuals are metabolically unhealthy, which makes it difficult to pinpoint who is at risk of associated diseases, and who is not.

"Certainly, being overweight generally increases your risk for cardiovascular disease, type 2 diabetes, and low-grade inflammation, but understanding the level of risk is important to better direct supports.

"In this study, we investigated the causal relationships of individuals within three metabolically different obesity types* ­– unfavourable, neutral and favourable – to establish whether specific weight groups were more at risk than others.

"Generally, the three obesity subtypes have a characteristic of higher body mass index, yet, each type varies in terms of body fat and visceral fat distribution, with a different risk of cardiometabolic diseases.

"We found that people with higher levels of obesity especially those with metabolically unfavourable and neutral adiposity subtypes had much lower levels of grey brain matter, indicating that these people may have compromised brain function which needed further investigation.

"However, we did not find conclusive evidence to link a specific obesity subtype with dementia or stroke. Instead, our study suggests the possible role of inflammation and metabolic abnormalities and how they can contribute to obesity and grey matter volume reduction."

The study used Mendelian randomisation to examine the genetic data of up to 336,000 individual records in the UK Biobank, with self-reported information and linked hospital and death register records to connect dementia and stoke.

It found that middle to elderly age groups (37-73) grey brain matter decreased by 0.3 per cent for every extra 1 kg/m2, which is equivalent of an extra 3 kg of weight for person of average height individuals, (173 cm)

Senior investigator, Professor Elina Hyppönen, Director of UniSA's Australian Centre for Precision Health based at SAHMRI, says maintaining a healthy weight is important for general public health.

"It is increasingly appreciated that obesity is a complex condition, and that especially excess fat which is located around the internal organs have particularly harmful effects on health," Professor Hyppönen says.

"Here, we used the individuals' genetic and metabolic profiles to confirm different types of obesity. In practice, our findings very much support the need to look at the type of obesity when assessing the type of likely health impact.

"Even in a relatively normal weight individual, excess weight around the abdominal area may be a cause of concern."

blood pressureheart eventsdementiastrokecardiovascular diseasebody mass index
Hina Zahid
Hina Zahid

    Hina Zahid Joined Medical Dialogue in 2017 with a passion to work as a Reporter. She coordinates with various national and international journals and association and covers all the stories related to Medical guidelines, Medical Journals, rare medical surgeries as well as all the updates in the medical field. Email: editorial@medicaldialogues.in. Contact no. 011-43720751

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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