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Higher levels of small dense LDL cholesterol robustly associated with increased risk of ischemic stroke
Researchers have found in a new study that Higher small dense low-density lipoprotein cholesterol levels were robustly associated with increased risk of ischemic stroke.
The study has been published in the journal Annals of Neurology.
For decades it has been suggested that small dense low-density lipoprotein (sdLDL) may be particularly atherogenic. High levels of small dense low-density lipoprotein are associated with an increased risk of ischemic heart disease; however, the association of small dense low-density lipoprotein (LDL) with ischemic stroke has not been explored in a large prospective study on the general population. We tested the hypothesis that high small dense low-density lipoprotein (LDL) cholesterol levels are associated with an increased risk of ischemic stroke.
This prospective study included 38,319 individuals from the Copenhagen General Population Study with fresh sample measurements of sdLDL cholesterol. Median follow-up time was 3.1 years. We observed 302 and 74 ischemic and haemorrhagic strokes from baseline in 2013-2017 to end of follow-up in 2018. They included estimates for large buoyant LDL cholesterol and total LDL cholesterol for comparison.
Reference:
Balling, M., Nordestgaard, B.G., Varbo, A., Langsted, A., Kamstrup, P.R. and Afzal, S. (2023), Small dense LDL cholesterol and ischemic stroke. Ann Neurol. Accepted Author Manuscript. https://doi.org/10.1002/ana.26598
Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751