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  • AstraZeneca eyes...

AstraZeneca eyes year-end filing for BP drug Baxdrostat

Written By : Ruchika Sharma |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2025-09-01T12:26:17+05:30  |  Updated On 1 Sept 2025 12:26 PM IST
AstraZeneca eyes year-end filing for BP drug Baxdrostat
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Bengaluru: AstraZeneca plans to seek regulatory approval for its experimental blood pressure drug, baxdrostat, by the end of the year, a senior company executive stated.

Ruud Dobber, president of AstraZeneca’s biopharmaceuticals unit, confirmed the timeline ahead of a presentation of advanced clinical trial data at a medical conference on Saturday. The company is targeting potential approvals in 2026, starting with the United States and the European Union.

Baxdrostat targets blood pressure-regulating hormone aldosterone, a novel approach compared with older treatments like diuretics and ACE inhibitors, which do not address hormonal drivers.

AstraZeneca expects peak annual sales for the drug to exceed $5 billion, Reuters
Keenly watched data showed that 2mg of baxdrostat, added to standard treatment, reduced systolic blood pressure by 9.8 millimetres of mercury (mmHg) from the baseline at 12 weeks, when adjusted for placebo, in patients with hard-to-control hypertension.
At the 1mg dose, that pressure exerted on the arteries by the heart's pumping action was lowered by 8.7 mmHg.
Physicians polled by TD Cowen wished to see a 10-12 mmHg fall in placebo-adjusted blood pressure, the brokerage said on Friday.
Mineralys Therapeutics' rival drug, lorundrostat, in March showed a placebo-adjusted reduction in systolic blood pressure by 9.1 mmHg at six weeks with a 50mg dose. The U.S. company also expects to submit data to the FDA by year-end.
"There's a huge acknowledgement that hypertension needs to be treated in a much more aggressive way," Dobber said.
High blood pressure affects over 1 billion people, according to the World Health Organization, and aggravates risk of heart attacks or strokes.
A small percentage of patients - 1.1% - taking baxdrostat developed hyperkalaemia, marked by high potassium levels in the blood. Hyperkalaemia was also observed with Mineralys' lorundrostat.
astrazenecaastrazeneca newsblood pressurebaxdrostatxruud dobberaldosteronediuretics
Ruchika Sharma
Ruchika Sharma

    Ruchika Sharma joined Medical Dialogue as an Correspondent for the Business Section in 2019. She covers all the updates in the Pharmaceutical field, Policy, Insurance, Business Healthcare, Medical News, Health News, Pharma News, Healthcare and Investment. She has completed her B.Com from Delhi University and then pursued postgraduation in M.Com. She can be contacted at editorial@medicaldialogues.in Contact no. 011-43720751

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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