Boehringer Ingelheim obtains two EU CVMP positive opinions for avian influenza vaccines

Both vaccines immunize birds against the H5 avian influenza virus, which is currently causing outbreaks across Europe.

Avian influenza, commonly referred to as avian flu or bird flu, is a highly contagious disease affecting domestic and wild birds. The H5 strain is one of the most prevalent avian influenza virus strains causing outbreaks in both wildlife and commercial flocks. As avian influenza is a highly regulated and notifiable disease, there is vigilant monitoring. To contain avian influenza outbreaks, large numbers of birds often need to be culled, leading to significant economic losses for poultry producers and possible restrictions in international trade.

As the virus continues to evolve, innovative vaccine solutions are an effective way to help prevent and manage avian flu outbreaks. Decisions regarding vaccination against avian influenza rest with the national authorities of each country. International institutions like WOAH (World Organization for Animal Health) recommend integrating vaccination into bird flu control strategies.

“Transboundary Animal Diseases like avian influenza will continue to be a threat, so new approaches to control these infectious diseases in animals, especially livestock, are increasingly important. Boehringer Ingelheim is committed to investing in research and innovation, and we are ready to support governments, health authorities and producers with our vaccines and expertise in monitoring and in setting up robust disease control plans,” says Armin Wiesler, Head of the Animal Health Business Unit and Member of the Board of Managing Directors.

Since 2021, highly pathogenic avian influenza H5 has caused unprecedented outbreaks, spreading across most continents globally and leading to massive poultry losses. The outbreaks have expanded to new regions such as Latin America and even Antarctica. The economic impact has been severe, with tremendous financial damage to the poultry industry, disruptions in egg and poultry meat availability, and trade restrictions.

VAXXITEK HVT+IBD+H5 and VAXXINACT H5 are so called DIVA (Differentiate Infected from Vaccinated Animals) vaccines that can play an important role in monitoring disease outbreaks. These vaccines include a biomarker that distinguishes the immune response to vaccination from antibodies caused by infection. In combination with surveillance efforts, DIVA vaccines are essential for reducing the risk of trade restrictions, as they enable both, exporters and importers to differentiate between vaccinated and infected animals, ensuring confidence in the safety of traded animal products.

“By continuously monitoring the efficacy of our vaccines and advancing our technologies, we ensure the right protection against the evolving avian influenza virus. The DIVA feature allows our customers to implement their surveillance programs and support safe trade while vaccinating,” says Taoufik Rawi, Head of Franchise, Poultry. “The positive opinions for VAXXITEK HVT+IBD+H5 and VAXXINACT H5 are critical to increase preparedness against avian influenza outbreaks in Europe.”

Following the CVMP’s positive opinions, the European Commission is expected to decide on marketing authorizations under exceptional circumstances in the coming months.