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Cecolin: WHO adds HPV vaccine for single dose use
WHO announced that a fourth WHO-prequalified human papillomavirus (HPV) vaccine product, Cecolin has been confirmed for use in a single-dose schedule. The decision is made based on new data on the product that fulfilled the criteria set out in the WHO’s 2022 recommendations for alternative, off-label use of HPV vaccines in single-dose schedules. This important milestone will contribute to improving sustainable supply of HPV vaccines—allowing more girls to be reached with the vaccines that prevent cervical cancer.
“Unlike most other cancers, we have the ability to eliminate cervical cancer, along with its painful inequities,” said Dr Tedros Adhanom Ghebreyesus, WHO Director-General. “By adding another option for a one-dose HPV vaccination schedule, we have taken another step closer to consigning cervical cancer to history.”
More than 95% of the 660 000 cervical cancer cases occurring globally each year are caused by HPV. Every two minutes, a woman dies from this preventable disease globally, and 90% of these deaths occur in low- and middle-income countries. Of the 20 hardest hit countries by cervical cancer 19 are in Africa.
HPV vaccine introductions have been hampered by global supply shortages since 2018 and production challenges encountered by one of the manufacturers earlier this year led to further shortfalls, potentially impacting millions of girls in need of HPV vaccines in Africa and Asia.
“Having 90% of girls fully vaccinated with the HPV vaccine by 15 years of age is the target for the first pillar of the WHO global strategy for cervical cancer elimination,” said Dr Kate O'Brien, Director of the Department of Immunization, Vaccines and Biologicals at WHO. “Given the continuing supply challenges, this addition of single-dose vaccine product means countries will have greater choice of vaccines to reach more girls.”
A growing number of vaccine products initially prequalified for use in a 2-dose schedule can now be used in a single-dose schedule. The single-dose use indication for this additional vaccine, Cecolin, is incorporated into the second edition of WHO’s technical document on considerations for HPV vaccine product choice. Like for other medications and vaccines, when there is data to support modified use, guided by a clear public health benefit, public health advisory bodies can recommend "off-label” use, until a manufacturer adds this modified use to their label.
Global data released on 15 July 2024 indicates that the one dose HPV vaccine coverage among girls aged 9-14 years increased from 20% in 2022 to 27% in 2023. In 2023, 37 countries were implementing the single-dose schedule. As of 10 September 2024, 57 countries are implementing the single-dose schedule. WHO estimates that the single-dose schedule adoption has resulted in at least 6 million additional girls being reached with HPV vaccines in 2023.
Earlier this year, countries and partners committed nearly US$ 600 million in new funding towards elimination of cervical cancer. Funding includes US$ 180 million from the Bill & Melinda Gates Foundation, US$ 10 million from UNICEF, and US$ 400 million from the World Bank. Together with the strong continuing commitment by Gavi, these investments will help to accelerate introductions and boost coverage of HPV vaccine among girls by 2030, according to WHO.
Read also: WHO approves first mpox diagnostic test for emergency use, boosting global access
Ruchika Sharma joined Medical Dialogue as an Correspondent for the Business Section in 2019. She covers all the updates in the Pharmaceutical field, Policy, Insurance, Business Healthcare, Medical News, Health News, Pharma News, Healthcare and Investment. She has completed her B.Com from Delhi University and then pursued postgraduation in M.Com. She can be contacted at editorial@medicaldialogues.in Contact no. 011-43720751
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751