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Novartis gets CDSCO panel nod to study anticancer drug JDQ443

New Delhi: Pharmaceutical major Novartis, has got a go-ahead from the Subject Expert Committee (SEC) functional under the Central Drug Standard Control Organization (CDSCO) to conduct the study of the anti-cancer JDQ443, an investigational selective, covalent, and orally bioavailable KRASG12C inhibitor.However, the approval is subject to a condition that the firm should update safety and...
New Delhi: Pharmaceutical major Novartis, has got a go-ahead from the Subject Expert Committee (SEC) functional under the Central Drug Standard Control Organization (CDSCO) to conduct the study of the anti-cancer JDQ443, an investigational selective, covalent, and orally bioavailable KRASG12C inhibitor.
KRAS mutations are the most frequent oncogenic drivers in non-small cell lung cancer (NSCLC), the most common type of lung cancer. The most common form of KRAS mutation is G12C4. JDQ443 inhibits this mutated form of KRAS in a structurally distinct way, trapping KRAS G12C in a GDP-bound, inactive state while avoiding direct interaction with H95, a recognized route for resistance. In preclinical models, JDQ443 potently inhibited KRAS G12C cellular signalling and proliferation in a mutant-selective manner and demonstrated dose-dependent antitumor activity
Doctor of Pharmacy
Dr. Divya Colin, a Doctor of Pharmacy Graduate with extensive experience in clinical and hospital settings and confidently equipped with diagnostic and therapeutic skills. She also has spread out exposure to Oncology Departments in Mysore Medical College and Research Institute as Oncology Pharmacist. Currently she is building a career in clinical research and clinical data management. She has been a part of Medical Dialogue since January 2022.