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  • Novo Nordisk hopes to...

Novo Nordisk hopes to launch weight loss pill Amycretin this decade

Written By : Ruchika Sharma |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2024-03-11T12:50:36+05:30  |  Updated On 20 March 2024 4:13 PM IST
As Ozempic, Wegovy Take Priority, Novo Nordisk Winds Down Insulin Portfolio In India
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Novo's current plan is to advance the development of amycretin in its oral and injectable form simultaneously, and it gives a regulatory advantage to deliver safety data on both versions at the same time, Lange said.

Denmark: Novo Nordisk is very comfortable it will be able to launch the pill version of its experimental weight loss drug amycretin this decade, the drugmaker's head of development told Reuters on Friday, a day after it announced strong early trial data on it.

"I never commit to timelines but I would be very comfortable to say at the very least within this decade," Martin Holst Lange said in an interview.
Novo shares surged more than 8 per cent to record highs on Thursday when the company told investors a Phase I trial of the pill version of amycretin showed participants lost 13.1 per cent of their weight after 12 weeks, a bigger reduction early on than from Wegovy.
Shares in the drugmaker, which surpassed Tesla Inc in market value on Thursday, were down 0.9 per cent on Friday but were still set for a 7.1 per cent gain this week.
Investors said the news shows the Danish company, originally known as an insulin maker, has more in its pipeline beyond its hugely successful Wegovy. Its shares have risen more than three-fold since June 2021 when it launched Wegovy in the United States.
It hopes both its new experimental obesity drugs cagrisema and amycretin will have higher efficacy in terms of weight-loss than Wegovy.
Cardiac Benefits
After 12 weeks on amycretin in the trial, more than 80 per cent of the participants were still on the drug, Lange said, describing it as an "impressive" retention rate which would suggest that the doses were safe and patients were tolerating it well without major side effects.
Lange added that it also "would be a likely scenario" that the new drugs would have similar cardiac benefits as Wegovy.
Wegovy belongs to a class of drugs known as GLP-1 agonists, originally designed to treat Type 2 diabetes, that have been shown to regulate blood glucose levels and suppress appetite.
Following the success of Wegovy, companies are working on other promising weight-loss therapies such as amycretin, which in addition to binding to the same gut hormone as Wegovy -- GLP-1 -- also targets a hormone called amylin in the pancreas that affects hunger.
Novo in August said a large study had shown Wegovy also had a clear cardiovascular benefit, boosting the company's hopes of moving beyond its image as a lifestyle drug.
Those results have led to a debate over whether the long-term medical benefits of weight-loss drugs are enough to reduce the overall burden on healthcare systems and the cost of treating heart disease in overweight and obese people.
Novo's current plan is to advance the development of amycretin in its oral and injectable form simultaneously, and it gives a regulatory advantage to deliver safety data on both versions at the same time, Lange said.
Read also: Novo Nordisk Wegovy gets USFDA nod for lowering heart risks
Original news source: https://www.reuters.com/business/healthcare-pharmaceuticals/novo-nordisk-hopes-launch-experimental-obesity-drug-within-this-decade-2024-03-08/
novo nordisknovo nordisk newsamycretinweight loss drugobesity
Ruchika Sharma
Ruchika Sharma

    Ruchika Sharma joined Medical Dialogue as an Correspondent for the Business Section in 2019. She covers all the updates in the Pharmaceutical field, Policy, Insurance, Business Healthcare, Medical News, Health News, Pharma News, Healthcare and Investment. She has completed her B.Com from Delhi University and then pursued postgraduation in M.Com. She can be contacted at editorial@medicaldialogues.in Contact no. 011-43720751

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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