SITC 2020: Dr Reddy's presents preclinical data for denileukin diftitox, immune checkpoint inhibitor
Hyderabad & Princeton: Dr. Reddy's Laboratories Ltd. has recently announced a preclinical data presentation for E7777 (denileukin diftitox), its engineered IL-2-diphtheria toxin fusion protein, at The Society for Immunotherapy of Cancer (SITC) 35th Anniversary Annual Meeting, being held virtually.
Dr. Anil Namboodiripad, Senior Vice President and Head of Dr. Reddy's Proprietary Products Division stated, "We are encouraged that in addition to the clinically demonstrated safety and activity of denileukin diftitox in patients with cutaneous T cell lymphoma, these new syngeneic mouse model studies show that E7777 also shows promising activity as a potential immunotherapy agent for treatment of solid tumors. Combination of E7777 with an anti-PD-1 agent provided clear benefit both in terms of tumor growth control, and a highly significant improvement in overall survival. We look forward to conducting clinical trials to further explore this combination."
Key findings from the presentation are included below.
Title: E7777 (Denileukin Diftitox) Enhances Anti-Tumor Activity and Significantly Extends Survival Benefit of Anti-PD-1 in Syngeneic Solid Tumor Models
- E7777 administered as monotherapy inhibited tumor growth with activity comparable to anti-PD-1 monotherapy in syngeneic murine tumor models
- Combination of E7777 and anti-PD-1 inhibited tumor growth substantially better than monotherapy treatments
- Administration of E7777 and anti-PD-1 for a limited treatment period led to highly significant improvements in long-term survival
- Combination of E7777 and anti-PD-1 was administration schedule independent
Dr. Reddy's Laboratories Ltd. is an integrated pharmaceutical company headquartered in Hyderabad, committed to providing affordable and innovative medicines for healthier lives.
Its major therapeutic areas of focus are gastrointestinal, cardiovascular, diabetology, oncology, pain management, and dermatology.