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Sun Pharma, Moebius Medical present positive data from phase 2b trial of MM-II in painful knee osteoarthritis patients at EULAR 2024

Written By : Ruchika Sharma |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2024-06-15T12:30:24+05:30  |  Updated On 15 Jun 2024 12:30 PM IST
Sun Pharma discontinues development of skin disease drug after trial dissapointment
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Sun Pharma and Moebius Medical, who have been jointly developing MM-II, have announced plans to initiate a Phase 3 clinical program.

Mumbai: Sun Pharma and Israel-based Moebius Medical Limited have presented data demonstrating the durability of pain relief achieved in symptomatic knee OA patients through 26 weeks post injection of MM-II. The results, presented at EULAR 2024, are based on an analysis from the randomized, controlled, Phase 2b clinical study (NCT04506463).

An abstract presenting the data, entitled “Duration of Clinically Meaningful Analgesic Response to Intra-Articular MM-II, A Novel Suspension of Large, Empty, Multilamellar Liposomes, in Patients with Painful Knee Osteoarthritis: Analysis from a 26-Week Phase 2b Randomised Controlled Trial”, was presented by Philip G. Conaghan, Professor of Musculoskeletal Medicine at the University of Leeds and Director of the NIHR Leeds Biomedical Research Centre.

Prof. Conaghan commented, “Given the limitations of many current therapies, there is an urgent need for more therapeutic treatment options for patients with painful osteoarthritis. Data from the 3mL dose of MM-II in this trial demonstrate MM-II’s potential to offer durable and meaningful pain relief with good tolerability.”

MM-II is a novel non-opioid product that uses a proprietary suspension of large, empty, multilamellar liposomes which are intended to reduce friction and wear on the joint and thus relieve joint pain. Sun Pharma and Moebius Medical, who have been jointly developing this product, have announced plans to initiate a Phase 3 clinical program and to seek a CE Mark for the product in the European Union.

Abhay Gandhi, CEO - North America Business, Sun Pharma, commented, “With over 100 million people currently suffering from joint pain, there is a significant unmet need for additional OA therapies. This analysis from our clinical trial is further confirmation of the potential role that MM-II will be able to play in improving painful OA treatment.”

Moshe Weinstein, CEO of Moebius Medical, added, “As more data become available, we continue to see MM-II’s potential as a safe and effective alternative to today’s OA treatments. We look forward to continuing development of our lead candidate with our partners at Sun Pharma.”

Osteoarthritis (OA) is a common chronic degenerative joint disease, characterized by progressive wear of joint cartilage. Clinical manifestations of OA in the knee include, but are not limited to, pain in and around the joint and limited joint motion. Due to the inability of joint cartilage to self-heal, OA is among the most challenging joint diseases to treat, and currently no cure exists. The focus of current OA treatments is to reduce pain and improve function of the affected joints. Global estimates of OA exceed 100 million, and symptomatic OA afflicts more than 30 million Americans. Loss of joint function as a result of this condition is a major cause of work disability and reduced quality of life.
Moebius Medical is a clinical stage biotechnology company that is developing novel pain relief treatments for osteoarthritis. The company was founded in 2008 within the RAD Biomed Accelerator to develop products based on a patent-protected technology licensed exclusively from Yissum, the Hebrew University Technology Transfer Company; T3, the Technology Transfer arm of the Technion Institute; and by Hadasit, the Technology Transfer company of Hadassah Medical Center. In 2016, Moebius entered a joint collaboration with Sun Pharma to develop MM-II.
Read also: Sun Pharma Labs gets CDSCO Panel nod to study synthetic-origin Semaglutide solution for injection
sun pharmasun pharma newsmoebius medicaloteoarthritisEULAR 2024
Ruchika Sharma
Ruchika Sharma

    Ruchika Sharma joined Medical Dialogue as an Correspondent for the Business Section in 2019. She covers all the updates in the Pharmaceutical field, Policy, Insurance, Business Healthcare, Medical News, Health News, Pharma News, Healthcare and Investment. She has completed her B.Com from Delhi University and then pursued postgraduation in M.Com. She can be contacted at editorial@medicaldialogues.in Contact no. 011-43720751

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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