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Upgraded version of COVID booster shot has potential against main variants: Sanofi
Paris: French drugmaker Sanofi said on Monday an upgraded version of the COVID-19 vaccine candidate it is developing with GSK showed potential in two trials to protect against the virus's main variants of concern, including the Omicron BA.1 and BA.2 strains, when used as a booster shot.
While the two companies' first experimental COVID shot is undergoing review by the European Medicines Agency, Sanofi and GSK have continued work on a vaccine that is molded on the now-supplanted Beta variant, hoping still that it will confer broad protection against future viral mutations.
Sanofi said this new vaccine candidate was shown to significantly boost antibody levels against a number of variants of concern, when given to trial participants who had an initial course of mRNA vaccines, a type made by BioNTech-Pfizer and Moderna.
Read also: Sanofi, IGM Biosciences collaborate for oncology, immunology, inflammation targets
In a separate trial conducted by a French hospitals network, Sanofi's Beta-adapted booster shot triggered a higher immune response than Sanofi's first-generation shot or Pfizer-BioNTech's established vaccine in previously vaccinated volunteers.
"The Beta variant expresses similar mutations across multiple variants of concern, including Omicron, making it a strong vaccine candidate to confer broad protection against multiple strains of COVID-19," said Thomas Triomphe, the head of Sanofi's vaccine business.
Read also: Sanofi gets USFDA breakthrough therapy designation for hemophilia A drug Efanesoctocog alfa
Highlighting the need for vaccine makers to address new variants of concern in a saturated COVID vaccine market, Valneva on Friday said it was in talks to try and salvage a supply agreement that the European Commission cancelled.
Valneva's product is based on the original virus found in the Chinese city of Wuhan, like BioNTech-Pfizer and Moderna's dominant first-generation shots
Read also: Sanofi Gets CDSCO panel okay for retrospective study of Insulin Glargine
Ruchika Sharma joined Medical Dialogue as an Correspondent for the Business Section in 2019. She covers all the updates in the Pharmaceutical field, Policy, Insurance, Business Healthcare, Medical News, Health News, Pharma News, Healthcare and Investment. She has completed her B.Com from Delhi University and then pursued postgraduation in M.Com. She can be contacted at editorial@medicaldialogues.in Contact no. 011-43720751