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Zydus to make typhoid-shigellosis vaccine for children

Written By : Ruchika Sharma |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2025-03-04T14:30:37+05:30  |  Updated On 4 March 2025 3:39 PM IST
Zydus to develop typhoid-shigellosis vaccine for children
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Ahmedabad: Global lifesciences company, Zydus Lifesciences Limited, has announced the development of a combination vaccine against shigellosis and typhoid.

Zydus will carry out early-stage development, animal immunogenicity studies and regulatory preclinical toxicology studies for this combination vaccine. The project is expected to get underway in March 2025, and is being supported by the Gates Foundation.

Zydus, a global lifesciences company specialising in novel, affordable and highly impactful vaccines will collaborate with a partner for the research and co-development of a combination vaccine using Zydus’ WHO prequalified Typhoid conjugate vaccine (ZyVac TCV) and Shigella Vaccine from Zydus’ partner.

Vaccination remains the most effective way of preventing and controlling the disease. The TCVShigella combination vaccine aims to protect children below 5 years against shigellosis, a diarrhoeal disease caused by the Shigella bacteria and typhoid fever, caused by salmonella bacteria in areas where both the diseases are endemic. This combination of vaccines, if found successful, will safeguard children against two lethal enteric diseases of global relevance and potentially offer a viable solution in a scenario where childhood immunization schedules are becoming increasingly crowded, expensive, and unsustainable.

Speaking on this development, Dr. Sharvil Patel, Managing Director, Zydus Lifesciences Limited said, “We welcome this opportunity to collaborate with Gates Foundation and our partner on the development of the TCV Shigella combination vaccine. It marks yet another step towards our ongoing commitment to addressing critical gaps through innovation. By collaborating with key partners and leveraging our research and development capabilities to provide novel solutions, we can bridge unmet needs through high-quality, and affordable vaccines that can create a sustainable impact in global public health.”

Sh. M Hari Menon, Country Director, Gates Foundation, added, “The Gates Foundation has always supported efforts that help save children’s lives. We are excited about supporting this initiative by Zydus, which would leverage India’s science and innovation expertise, and has the potential to contribute significantly to protecting children, not just in India, but also in other parts of the world."
Typhoid is already a disease of concern globally and various endemic countries already have TCV as part of their national immunization plan. GAVI board also approved a learning agenda on vaccination against shigella for 2026 to 2030 immunization strategy. An estimated 11–21 million cases of typhoid fever and 5 million cases of paratyphoid fever occur worldwide each year, causing an estimated 135,000–230,000 deaths.
Shigella was the second-leading cause of diarrhoeal mortality in 2016 among all ages, and the leading bacterial cause of diarrhoea, accounting for approximately 212 000 deaths and about 13% of all diarrhoeaassociated deaths. Recently in Dec’24 WHO has published the global priority endemic pathogens for vaccine research and development (R&D) where Shigella is pathogen of concern for Africa, American, Eastern Mediterranean, European, and Southeast Asian regions.


zydus lifesciencesshigellosistyphoidgates foundationZyVac TCVTCVShigella
Ruchika Sharma
Ruchika Sharma

    Ruchika Sharma joined Medical Dialogue as an Correspondent for the Business Section in 2019. She covers all the updates in the Pharmaceutical field, Policy, Insurance, Business Healthcare, Medical News, Health News, Pharma News, Healthcare and Investment. She has completed her B.Com from Delhi University and then pursued postgraduation in M.Com. She can be contacted at editorial@medicaldialogues.in Contact no. 011-43720751

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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