Antioxidant in mushrooms may help relieve preeclampsia symptoms
Denmark: Preeclampsia is a multifactorial hypertensive disorder of pregnancy founded on abnormal placentation, and the resultant placental ischemic microenvironment is thought to play a crucial role in its pathophysiology. Pregnancy hypertension, or Pre-eclampsia, is a complex disorder of pregnancy. Treatment of elevated blood pressure can manage the condition in the mother, but in severe...
Denmark: Preeclampsia is a multifactorial hypertensive disorder of pregnancy founded on abnormal placentation, and the resultant placental ischemic microenvironment is thought to play a crucial role in its pathophysiology. Pregnancy hypertension, or Pre-eclampsia, is a complex disorder of pregnancy. Treatment of elevated blood pressure can manage the condition in the mother, but in severe cases delivery is needed, which can present a major problem to the baby if it is born prematurely.
Researchers at the Department of Pharmacology & Therapeutics at University College Cork (UCC), the INFANT Centre at UCC and the University of Liverpool, as well as the Novo Nordisk Foundation Center for Biosustainability (DTU Biosustain) at Technical University of Denmark, have shown in a rat model that a natural diet? derived antioxidant L-ergothioneine can relieve some of the clinical symptoms of Pre-eclampsia. The hope is that the same will be in evidence in humans. The study has been published in Journal Hypertension.
"Our research shows that treating rats with pre-eclampsia with the natural antioxidant L-ergothioneine reduced blood pressure, prevented fetal growth restriction and dampened production of the damaging substances released from the placenta during pre-eclampsia," says Dr Cathal McCarthy, leader of this research in a press release from the INFANT Centre at UCC.
In order to be able to make enough L-ergothioneine to eventually treat patients, the scientists are looking into ways of producing this compound efficiently in high amounts using yeast cell factories. Ergothioneine can be found in a wide variety of foods, but in particular in mushrooms, where amounts are relatively high compared to other foods.
"Today, ergothioneine is either made chemically or extracted from mushrooms, but at DTU Biosustain we are developing a method to make it biologically. This should lead to its much wider availability at competitive prices," says Douglas Kell, Associated Scientific Director at DTU Biosustain and Research Chair in Systems Biology Department of Biochemistry, University of Liverpool. At DTU Biosustain, Douglas Kell and his team work closely together with the group of Senior Researcher Irina Borodina to produce L-ergothioneine biologically using advanced genomic engineering.
Much evidence exists for L-ergothioneine's benefits in a variety of neurological and vascular disorders as well. Thus, L-ergothioneine appears to be a safe, natural diet? derived antioxidants whose therapeutic potential looks promising but remains to be validated in human clinical trials.
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Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Before Joining Medical Dialogues, he has served at important positions in the medical industry in India including as the Hony. Secretary of the Delhi Medical Association as well as the chairman of Anti-Quackery Committee in Delhi and worked with other Medical Councils in India. Email: email@example.com. Contact no. 011-43720751