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  • Cabergoline Prevents...

Cabergoline Prevents Breast Symptoms After Second-Trimester Abortion or Pregnancy Loss: Study

Written By : Aditi |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2023-06-23T09:45:54+05:30  |  Updated On 23 Jun 2023 2:12 PM IST
Cabergoline Prevents Breast Symptoms After Second-Trimester Abortion or Pregnancy Loss: Study
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A study published in Obstetrics & Gynecology has concluded that a one-time dose of Cabergoline is superior to a placebo in preventing breast symptoms after second-trimester abortion or pregnancy loss. Fewer people receiving Cabergoline were significantly bothered by breast symptoms, researchers said.

The study entitled "Cabergoline for Lactation Inhibition After Second-Trimester Abortion or Pregnancy Loss" is led by Dr Henkel, Andrea MD, MS and colleagues.

In this double-blinded, block-randomized superiority trial, researchers assessed Cabergoline's efficacy at decreasing breast symptoms after second-trimester abortion or pregnancy loss and enrolled pregnant women 18–28 weeks of gestation (English- or Spanish-speaking) and without contraindication to the study drug.

The primary outcomes measured were the breast symptoms a composite of engorgement, milk leakage, tenderness, and need for pain relief) on day 4.

The study results are:

  • One hundred fifty patients were screened, out of which 73 participants were enrolled.
  • Baseline demographics were balanced between groups: median gestational age was 21 weeks (range 18–26 weeks), 56.2% of participants were nulliparous, 34.2% self-identified as Hispanic, and 37.0% had public insurance.
  • There were similarities in reported breast symptoms at baseline between groups.
  • Among 69 participants who returned surveys on day 4, significantly fewer participants receiving Cabergoline reported breast symptoms than placebo, and recording was 27.8% vs 97.0%.
  • These differences persisted through day 14.
  • There were similarities in Reported incidence and severity of side effects between groups, with constipation, fatigue and headache as the most common.
  • There were similarities in Serum prolactin levels at baseline.
  • The mean serum prolactin level for those receiving Cabergoline and placebo was 6.5 ng/mL and 18.0 ng/mL, respectively, on day 4

They said, "We selected a dose of 1 mg of cabergoline based on existing formulary options of 0.5 mg tabs and prior dose-finding studies that supported higher efficacy with higher doses."

Concluding further, they said, based on the study results, they find Cabergoline an effective and well-tolerated strategy for preventing breast symptoms after second-trimester abortion or pregnancy loss.

The study strengths were study design, diverse population, questionnaires, and lack of industry sponsorship.

They said our primary outcome was clinically meaningful and person-centred, allowing broad generalizability of results.

However, the study had limitations like low trial acceptance, underpowered to detect minor differences in side effects, lack of gestational age stratification in the original randomization scheme, restricted external validity, ad small sample size.

Further reading:

https://journals.lww.com/greenjournal/Fulltext/2023/06000/Cabergoline_for_Lactation_Inhibition_After.11.aspx

cabergolinebreast symptomssecond-trimester abortionpregnancy lossObstetrics and Gynaecology
Source : Obstetrics & Gynecology
Aditi
Aditi

    BDS, MDS in Periodontics and Implantology

    Dr. Aditi Yadav is a BDS, MDS in Periodontics and Implantology. She has a clinical experience of 5 years as a laser dental surgeon. She also has a Diploma in clinical research and pharmacovigilance and is a Certified data scientist. She is currently working as a content developer in e-health services. Dr. Yadav has a keen interest in Medical Journalism and is actively involved in Medical Research writing.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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