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  • Early Menarche Linked...

Early Menarche Linked to Higher Cardiovascular Risk in Women, suggests study

Written By : Dr Riya Dave |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2025-02-07T20:30:00+05:30  |  Updated On 8 Feb 2025 12:06 PM IST
Early Menarche Linked to Higher Cardiovascular Risk in Women,  suggests study
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A new study published in Scientific Reports has found that age at menarche (AAM) can be an important indicator of the risk of developing cardiovascular disease (CVD). The study conducted in Iran analyzed the association between AAM and several CVD risk factors in women aged 35–65 years and assessed their anthropometric, demographic, and biochemical profiles as well as the levels of depression and anxiety. The study was conducted by Niloofar S. and colleagues.

This cross-sectional study used data from the Mashhad cohort study, Mashhad, Iran. Participants self-reported their AAM. Demographic data, anthropometric measurements such as weight, height, BMI, WC, HC, and WTR were taken. Biochemical markers were also collected. The Persian versions of the Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) were used to assess psychological factors like depression and anxiety. Multiple logistic regression models were applied to determine the relationship between AAM and CVD risk factors.

Key Findings

Women who started their menstruation at ≤11 years had higher weight (p< 0.001), BMI (p< 0.001), HC (p<0.001), and WTR (p<0.001) as compared to the women with AAM ≥15 years.

• The odds of having BMI >28.7 kg/m², WC >96 cm, HC >105 cm, and WTR >61.96 among women who experienced their first menstruation at ≤11 years was greater than among women who first menstruated at 13 years.

• Women with menarche at 12 years had higher odds of diabetes mellitus and HC >105 cm than those with menarche at 13 years.

• University-educated and employed women were more likely to have menarche at ≥15 years (p< 0.001 and p=0.012, respectively).

• Women with AAM ≥15 years had a lower likelihood of depression (BDI score >12) compared to those with earlier menarche.

• Girls who attained menarche at the age of 14 had greater odds in relation to both height >155 cm and demi-span >74 cm compared with those attaining menarche at 13 years.

Researchers concluded that early menarche is associated with increased cardiovascular risk factors, including obesity, diabetes, and metabolic imbalances. Identifying women with early menarche can help implement preventive strategies to reduce long-term health risks. Future research should explore potential genetic and environmental influences on menarche timing and cardiovascular health outcomes.

Reference:

Shabani, N., Saffar Soflaei, S., Bavafa-Valenlia, K. et al. The association between age at menarche (AAM) and cardiovascular disease (CVD) risk factors in the MASHAD cohort study. Sci Rep 15, 3518 (2025).https://doi.org/10.1038/s41598-024-83763-z

Scientific ReportsAge at menarchecardiovascular diseasediabetesobesityIranrisk factors
Source : Scientific Reports
Dr Riya Dave
Dr Riya Dave

    Dr Riya Dave has completed dentistry from Gujarat University in 2022. She is a dentist and accomplished medical and scientific writer known for her commitment to bridging the gap between clinical expertise and accessible healthcare information. She has been actively involved in writing blogs related to health and wellness.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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