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Hormone Therapy Linked to Slower Biological Aging and Lower Mortality in Postmenopausal Women, Study Finds
China: A recent study published in JAMA Network Open has uncovered intriguing findings regarding hormone therapy (HT) and its impact on biological aging in postmenopausal women.
The research reveals that women who have historically used HT appear biologically younger than their counterparts who have not received this treatment. This effect is particularly pronounced among women of lower socioeconomic status (SES), suggesting that HT might play a crucial role in promoting healthier aging.
Hormone therapy, commonly prescribed to alleviate symptoms associated with menopause, has been the subject of extensive research. Yufan Liu and Chenglong Li from Capital Medical University, Beijing, China, aimed to evaluate the association between HT use and discrepancies between chronological and biological age in postmenopausal women and the potential modifying role of SES.
The population-based, retrospective cohort study focused on postmenopausal women registered in the UK Biobank. Data collection included a baseline survey on hormone therapy (HT) use and biological aging biomarkers, conducted between March 2006 and October 2010, with data analyses completed in December 2023.
Information on HT use, including the age at HT initiation and its duration, was gathered through a touchscreen questionnaire. Socioeconomic status was assessed using measures of education, family income, occupation, and the Townsend Deprivation Index.
The study evaluated biological aging discrepancy by calculating validated phenotypic age, which combines chronological age with nine biomarkers measured at baseline. Additionally, the study assessed all-cause and cause-specific mortality to further understand the impact of HT on health outcomes.
The researchers reported the following findings:
- Among the 117 763 postmenopausal women (mean age, 60.2 years), 40.3% ever used HT. The mean phenotypic age was 52.1 years.
- Ever use of HT was associated with a smaller biological aging discrepancy than never use of HT (β, −0.17 years). This smaller aging discrepancy was more evident in those who started HT at age 55 years or older (β, −0.32 years) and those who used HT for 4 to 8 years (β, −0.25 years).
- The association between HT and a smaller aging discrepancy was more evident in women with low SES, with a significant interaction observed for education (higher education: β, −0.08 years; other education: β, −0.23 years).
- Phenotypic aging discrepancy mediated 12.7% of the association between HT and all-cause mortality and cause-specific mortality.
"These findings endorse the use of hormone therapy in postmenopausal women as a means to support healthy aging and address associated health inequalities. However, further research is needed to validate the clinical benefits of this treatment," the researchers concluded.
Reference:
Liu Y, Li C. Hormone Therapy and Biological Aging in Postmenopausal Women. JAMA Netw Open. 2024;7(8):e2430839. doi:10.1001/jamanetworkopen.2024.30839
MSc. Biotechnology
Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at  editorial@medicaldialogues.in. Contact no. 011-43720751
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751