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Maternal exposure to ultrafine particles increases risk for flu during pregnancy
USA: Exposure to ultrafine particles (UFPs) during pregnancy enhances respiratory viral infection risk, says a recent study published in Particle and Fibre Toxicology.
During pregnancy, women are more susceptible to severe respiratory infections from multiple viruses, including influenza A virus (IAV), respiratory syncytial virus (RSV) and severe acute respiratory syndrome coronavirus (SARS-CoV-2). Additionally, pregnant women are disproportionately affected by influenza, resulting in a more than 10-fold increase in hospitalization risk.
“We know that air pollution affects the pulmonary immune system, making individuals more susceptible to viral infections,” said Dr Natalie Johnson, associate professor in the Texas A&M University School of Public Health’s Department of Environmental and Occupational Health. “We also know pregnant women are already at increased risk for severe flu. Surprisingly, studies have not interrogated the combined effects of pregnancy, air pollution and influenza. Our findings demonstrate the need to study these interactions further to prevent short and perhaps long-term impacts on maternal health.”
In the study, Johnson and her co-authors point out that several physiological characteristics explain maternal susceptibility to viral infection. Among those are increased cardiac output and decreased tidal volume-the amount of air that moves in or out of the lungs with each respiratory cycle — as well as immunological changes such as selective modulation of immune cell subsets to protect the developing fetus.
The research team also highlights that vaccination compliance during pregnancy is generally below 50 percent, despite vaccination against influenza being safe and effective, leading to an increased risk of developing respiratory infection.
As a result, air pollution, a worldwide environmental health issue, is responsible for one in nine deaths, with an annual premature mortality of more than 7 million. A mixture of gases and tiny airborne particulate matter, categorized as UFPs, is critical to recognize and identify, especially to protect vulnerable populations.
The research team says these findings support future clinical and regulatory interventions for protecting pregnant women and controlling UFPs. According to the researchers, it is imperative that pregnant women in urban cities, where influenza and UFPs are more prevalent, are provided vaccinations and preventive measures limiting UFP exposure to protect maternal health.
“Air pollution is a pervasive environmental health issue,” Johnson said. “Strategies to protect the most vulnerable, like pregnant women, are highly prioritised to decrease adverse health effects.”
Reference:
Drury, N.L., Mustapha, T., Shore, R.A. et al. Maternal exposure to ultrafine particles enhances influenza infection during pregnancy. Part Fibre Toxicol 20, 11 (2023). https://doi.org/10.1186/s12989-023-00521-1.
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751