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Treatment for Recurrent Uterine Cancer Advances to Next Research Phase

Dr. Kamal Kant KohliWritten by Dr. Kamal Kant Kohli Published On 2024-08-02T20:00:40+05:30  |  Updated On 2 Aug 2024 8:01 PM IST
Treatment for Recurrent Uterine Cancer Advances to Next Research Phase
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The latest trial of a new antibody drug that delivers potent chemotherapy directly to cancer cells for patients with advanced or recurrent endometrial cancer moves ahead to be studied further in a phase III trial.

Results of the phase II study led by Yale Cancer Center (YCC) researchers at Yale School of Medicine looked at the antibody drug conjugate sacituzumab govitecan (SG)-also known as Trodelvy.

The study’s results were published in the Journal of Clinical Oncology. The trial was sponsored by Gilead Sciences, Inc.

The findings are hopeful for patients with endometrial cancer (a type of uterine cancer), which is the most common gynecological cancer and the sixth most common cancer in women globally, with over 417,000 new cases and 97,000 deaths reported in 2020. When the combination first-line treatment for patients with advanced or recurrent endometrial cancer fails, there are currently few options.

"This is the first publication demonstrating the clinical activity of Trodelvy in uterine cancer," said the study’s first author Alessandro Santin, MD, professor of obstetrics, gynecology, and reproductive sciences at Yale School of Medicine and clinical research team leader for Gynecological Oncology at Yale Cancer Center. "In collaboration with Immunomedics and more recently Gilead investigators, I have been working with this antibody drug conjugate in my lab since the beginning of its development. This is a major 'bench-to-bedside' accomplishment for uterine cancer patients.”

SG is also being explored for its usefulness in delivering chemotherapy into the cancer cells of multiple types of metastatic solid tumors.

In the TROPiCS-03 phase II basket study (a study that looks at drug effectiveness in patients who have different cancers, but share the same biomarker), patients received 10 milligrams per kilogram of SG on day one and day eight of a 21-day cycle. In a heavily pretreated population (that is, patients had already received multiple rounds of chemotherapy and immunotherapy) with advanced, recurrent endometrial cancer, 22% responded to the treatment. Researchers reported that 61% of patients had a reduction in target lesions (22% of the patients fulfilled the criteria of partial response which was a 30% or more decrease in the size of the tumor). In patients that responded to the treatment, cancers remained stable for an average of 8.8 months without progressing.

As the trial continues, 29% of patients are still on treatment. No safety concerns were identified in the trial, and patients experienced manageable side effects such as fatigue and nausea.

Dr. Santin said the results of this trial, TROPiCS-03, mean researchers will be able to move forward to a phase III trial.

Reference:

Alessandro D. Santin, Bradley R. Corr, Alexander Spira, Lyndsay Willmott, James Butrynski, Ka Yu Tse, Jilpa Patel, Sabeen Mekan, Tia Wu, Kai-Wen Lin, Peiwen Kuo, and Ecaterina E. Dumbrava, Efficacy and Safety of Sacituzumab Govitecan in Patients With Advanced Solid Tumors (TROPiCS-03): Analysis in Patients With Advanced Endometrial Cancer, Journal of Clinical Oncology, https://doi.org/10.1200/JCO.23.02767.

Journal of Clinical OncologyUterine CancerCancersacituzumab govitecan
Source : Journal of Clinical Oncology
Dr. Kamal Kant Kohli
Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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