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  • Use of low-calorie...

Use of low-calorie sweeteners during pregnancy may increase weight of infants

Written By : Hina Zahid |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2020-01-30T15:57:26+05:30  |  Updated On 30 Jan 2020 3:57 PM IST
Use of low-calorie sweeteners during pregnancy may increase weight of  infants
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Many people turn to artificial or so-calleUse d natural sweeteners to cut calories and lose weight. Time and again there have been studies favouring their use and safety concerns regarding them.

Dr Raylene Reimer and colleagues have discovered that the consumption of low-calorie sweeteners by women during pregnancy increased body fat in their offspring and disrupted their gut microbiota - the trillions of bacteria and other microorganisms that inhabit the intestinal tract and affect our health and risk of numerous diseases. The findings are significant as they impact the critical early years of life, particularly during pregnancy and breastfeeding. The study has been published in the journal Gut.

"Low-calorie sweeteners are considered safe to consume during pregnancy and lactation, however evidence is emerging from human studies to suggest they may increase body weight and other cardiovascular risk factors," says Reimer, a University of Calgary professor in the Faculty of Kinesiology, and Department of Biochemistry & Molecular Biology at the Cumming School of Medicine, and member of the Alberta Children's Research Institute.

"Even stevia, which is hailed as a natural alternative to aspartame and other low-calorie artificial sweeteners, showed a similar impact on increasing offspring obesity risk in early life."

Aspartame, an artificial sweetener, and stevia, a natural low-calorie sweetener extracted from a plant native to South America, are 200-400 times sweeter than sugar. Stevia, gaining popularity, was historically used in Paraguay and Brazil to treat diabetes and is an emerging ingredient in many natural products and protein drinks.

Demand for sweeteners for weight loss

In response to higher obesity rates, the use of low-calorie sweeteners has risen, particularly in women and children. Daily consumption is associated with large babies and early menstruation in young females under 10 years - a known risk factor for chronic diseases. Additionally, the presence of some but not all of these sweeteners has been detected in breastmilk presenting a potential mode of transmission, according to the study.

"Understanding the impact of dietary ingredients on maternal metabolism and gut microbiota may help to define the optimal maternal diet, one which promotes a healthier future for both mother and child," says Reimer.

Altering the gut microbiota of babies

Our understanding of how sweeteners affect weight gain is not complete but there is reason to believe that alterations in the gut microbiota may play a key role. In this animal study, a fecal transplant was used to show the direct influence of altered gut microbiota on causing the increased obesity risk. Transplanting fecal matter from the offspring of mothers that consumed the low-calorie sweeteners into sterile, germ-free mice caused the mice to gain more weight and have worse blood glucose control. Even though the offspring had never consumed the sweeteners themselves, the changes to mom's microbiota and the metabolism were sufficient to change the microbiota in their offspring and trigger obesity.

"A healthy pregnancy, including good nutrition, is important for a healthy baby," says Reimer. "Our research will continue to examine what makes an optimal diet and more importantly seek to find ways to correct disruptions to gut microbiota should they occur."

For more details click on the link: http://dx.doi.org/10.1136/gutjnl-2018-317505

Source : Gut
Hina Zahid
Hina Zahid

    Hina Zahid Joined Medical Dialogue in 2017 with a passion to work as a Reporter. She coordinates with various national and international journals and association and covers all the stories related to Medical guidelines, Medical Journals, rare medical surgeries as well as all the updates in the medical field. Email: editorial@medicaldialogues.in. Contact no. 011-43720751

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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