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  • Adjuvant Olaparib in...

Adjuvant Olaparib in gBRCA+ Breast Cancer; decreases invasiveness and metastasis: study

Dr. Shravani DaliWritten by Dr. Shravani Dali Published On 2022-04-30T09:00:49+05:30  |  Updated On 30 April 2022 3:30 AM GMT
Adjuvant Olaparib in gBRCA+ Breast Cancer; decreases invasiveness and metastasis: study
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Adjuvant Olaparib in gBRCA+ Breast Cancer; decreases invasivenes and metastasis, according to a recent study published in The New England Journal of Medicine. Poly(adenosine diphosphate–ribose) polymerase inhibitors target cancers with defects in homologous recombination repair by synthetic lethality. New therapies are needed to reduce recurrence in patients with BRCA1 or BRCA2...

Adjuvant Olaparib in gBRCA+ Breast Cancer; decreases invasivenes and metastasis, according to a recent study published in The New England Journal of Medicine.

Poly(adenosine diphosphate–ribose) polymerase inhibitors target cancers with defects in homologous recombination repair by synthetic lethality. New therapies are needed to reduce recurrence in patients with BRCA1 or BRCA2 germline mutation–associated early breast cancer.

Researchers conducted a phase 3, double-blind, randomized trial involving patients with human epidermal growth factor receptor 2 (HER2)–negative early breast cancer with BRCA1 or BRCA2 germline pathogenic or likely pathogenic variants and high-risk clinicopathological factors who had received local treatment and neoadjuvant or adjuvant chemotherapy. Patients were randomly assigned (in a 1:1 ratio) to 1 year of oral olaparib or placebo. The primary end point was invasive disease–free survival.

The results are:

A total of 1836 patients underwent randomization. At a prespecified event-driven interim analysis with a median follow-up of 2.5 years, the 3-year invasive disease–free survival was 85.9% in the olaparib group and 77.1% in the placebo group (difference, 8.8 percentage points; 95% confidence interval [CI], 4.5 to 13.0; hazard ratio for invasive disease or death, 0.58; 99.5% CI, 0.41 to 0.82; P<0.001). The 3-year distant disease–free survival was 87.5% in the olaparib group and 80.4% in the placebo group (difference, 7.1 percentage points; 95% CI, 3.0 to 11.1; hazard ratio for distant disease or death, 0.57; 99.5% CI, 0.39 to 0.83; P<0.001). Olaparib was associated with fewer deaths than placebo (59 and 86, respectively) (hazard ratio, 0.68; 99% CI, 0.44 to 1.05; P=0.02); however, the between-group difference was not significant at an interim-analysis boundary of a P value of less than 0.01. Safety data were consistent with known side effects of olaparib, with no excess serious adverse events or adverse events of special interest.

Thus, among patients with high-risk, HER2-negative early breast cancer and germline BRCA1 or BRCA2 pathogenic or likely pathogenic variants, adjuvant olaparib after completion of local treatment and neoadjuvant or adjuvant chemotherapy was associated with significantly longer survival free of invasive or distant disease than was placebo. Olaparib had limited effects on global patient-reported quality of life.

Reference:

Adjuvant Olaparib for Patients with BRCA1- or BRCA2-Mutated Breast Cancer by Andrew N.J et al. published in the New England Journal of Medicine.

https://www.nejm.org/doi/full/10.1056/NEJMoa2105215

Keywords:

Adjuvant Olaparib in gBRCA+ Breast Cancer, Adjuvant Olaparib and gBRCA+ Breast Cancer, Breast Cancer cure, breast cancer treatment, invasivenes and metastasis of breast cancer, BRCA2-Mutated Breast Cancer, Andrew N.J. Tutt, Judy E. Garber, Bella Kaufman, Giuseppe Viale, Debora Fumagalli, Priya Rastogi, Richard D. Gelber, Evandro de Azambuja, Anitra Fielding, Judith Balmaña, Susan M. Domchek, Karen A. Gelmon,


Adjuvant OlaparibgBRCABreast CancerBRCA2-Mutated Breast Cancer
Source : The New England Journal of Medicine.
Dr. Shravani Dali
Dr. Shravani Dali

    BDS

    Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.

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