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  • Autism spectrum...

Autism spectrum disorder tied with Increased Cancer risk: study

Written By : Dr. Shravani Dali |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-07-08T20:00:27+05:30  |  Updated On 8 July 2022 8:00 PM IST
Autism spectrum disorder tied with Increased Cancer risk: study
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Autism spectrum disorder is tied to increased cancer risk according to a recent study published in the Annals of Oncology

Whether individuals with autism spectrum disorders (ASDs) have a higher-than-expected risk of cancer remains unknown.

Researchers carried out a population-based cohort study including 2.3 million individuals live-born to mothers from Nordic countries during 1987-2013 in Sweden with follow-up through 2016 (up to age 30 years). Individuals with autism spectrum disorder were ascertained through the Swedish National Patient Register. They estimated the relative risk of cancer in relation to autism spectrum disorder by odds ratios (ORs) and associated 95% confidence intervals (CIs) derived from logistic regression, after detailed adjustment for potential confounders. They also carried out a sibling comparison to address familial confounding and genetic correlation analysis using the genome-wide association study summary statistics to address confounding due to potential polygenetic pleiotropy between ASD and cancer.

Results:

  • Researchers observed an overall increased risk of any cancer among individuals with autism spectrum disorder, compared with individuals without autism spectrum disorder.
  • The association for any cancer was primarily noted for narrowly defined autistic disorder and autism spectrum disorder with comorbid birth defects or both birth defects and intellectual disability
  • An association was also suggested for autism spectrum disorder with comorbid ID, but was not statistically significant.
  • Autism spectrum disorder alone (i.e. without comorbid ID or birth defects) was not associated with an increased risk of any cancer
  • Sibling comparison and genetic correlation analysis showed little evidence for familial confounding or confounding due to polygenetic pleiotropy between autism spectrum disorder and cancer.

Autism spectrum disorder per se is not associated with an increased risk for cancer in early life. The increased cancer risk among individuals with autism spectrum disorder is likely mainly attributable to co-occurring ID and/or birth defects in autism spectrum disorder.

Reference:

Liu Q, Yin W, Meijsen JJ, Reichenberg A, Gådin JR, Schork AJ, Adami HO, Kolevzon A, Sandin S, Fang F. Cancer risk in individuals with an autism spectrum disorder. Ann Oncol. 2022 Jul;33(7):713-719. doi: 10.1016/j.annonc.2022.04.006. Epub 2022 Apr 14. PMID: 35430370.

Keywords:

Autism, spectrum, disorder, increased, cancer, risk, Oncology, Vaccination, epidemiology; population-based, Q Liu 1, W Yin, J J Meijsen, A Reichenberg, J R Gådin, A J Schork, H-O Adami, A Kolevzon, S Sandin, F Fang, Annals of Oncology


Annals of OncologyCancer riskautism spectrum disorder
Source : Annals of Oncology
Dr. Shravani Dali
Dr. Shravani Dali

    Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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