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Breast cancer drug shows potential for treatment of rare appendix cancer, suggests study

Dr. Kamal Kant KohliWritten by Dr. Kamal Kant Kohli Published On 2024-11-03T21:15:27+05:30  |  Updated On 4 Nov 2024 1:11 PM IST
Breast cancer drug shows potential for treatment of rare appendix cancer,  suggests study
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Researchers at University of California San Diego School of Medicine found an FDA-approved drug used to treat breast cancer has the potential to be an effective therapeutic for a specific type of appendix cancer.

The clinical trial results, publishing in the October 16, 2024 online edition of the Journal of Clinical Oncology, showed the oral medication, known as palbociclib, stabilized tumor growth and reduced blood tumor marker levels in patients with peritoneal mucinous carcinomatosis (PMC). This form of cancer originates in the appendix and is often resistant to standard chemotherapy.

“Finding that a breast cancer drug is successful in treating a subset of appendix cancer — where treatment options are currently limited — marks a significant advancement in our fight against this disease,” said co-senior author Andrew Lowy, MD, professor in the Department of Surgery and chief of the Division of Surgical Oncology at UC San Diego School of Medicine and clinical director for cancer surgery at Moores Cancer Center at UC San Diego Health. “This breakthrough introduces the first targeted therapy for this rare cancer.”

Appendix cancer is extremely uncommon, accounting for less than 1% of all gastrointestinal cancers, with the American Cancer Society estimating fewer than 2,000 cases diagnosed in the U.S. each year.

The study cohort involved 16 participants diagnosed with PMC, most of whom had previously received other treatments without success. Researchers analyzed the genetic mutations present within these cancers and found that tumors with mutations in one specific gene, GNAS, responded well to the drug. In these patients, blood markers associated with cancer activity were reduced in more than 80% of patients.

Laboratory results also showed that the drug slowed or stopped the multiplication of cancer cells, offering a well-tolerated alternative to chemotherapy, which is often associated with severe side effects.

“This medication can be implemented immediately without the need to wait for a new drug to be developed or for FDA approval,” said co-senior author Shumei Kato, MD, associate professor of medicine at UC San Diego School of Medicine and medical oncologist at UC San Diego Health.

Kato, who is also a UC San Diego Moores Cancer Center member, adds that the study underscores the advanced use of existing cancer treatments.

“The findings signal a promising new era for the treatment of appendix cancer and potentially other rare cancers with similar genetic mutations.”

Next steps include investigating how combining this drug with both traditional chemotherapies and newer targeted therapies could further enhance its effectiveness.

“This groundbreaking study validates our unique position as the only National Cancer Institute (NCI)-designated Comprehensive Center in the region and our commitment to discovering and offering the most leading-edge treatment options,” said Diane Simeone, MD, director of Moores Cancer Center at UC San Diego Health. “As an academic medical center, our clinical researchers are leading trials that are identifying promising new treatments and providing hope for patients who previously had few options.”

Journal of Clinical Oncologybreast cancercancerappendix cancerpalbociclib
Source : Journal of Clinical Oncology
Dr. Kamal Kant Kohli
Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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