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  • Immunotherapy may play ...

Immunotherapy may play role in treating nonmetastatic gastroesophageal cancer

Dr. Kamal Kant KohliWritten by Dr. Kamal Kant Kohli Published On 2022-05-17T19:45:26+05:30  |  Updated On 2022-05-17T20:34:33+05:30
Immunotherapy may play role in treating nonmetastatic gastroesophageal cancer
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ROCHESTER, Minn: Immunotherapy has transformed treatment for patients with stage 4 metastatic esophageal and gastric cancers. In patients with these malignancies, immunotherapy has been shown to prolong survival when patients' tumors exhibit a high expression of an immune-related protein called PD-L1. Researchers are now investigating whether immunotherapy benefits patients who do not have...

ROCHESTER, Minn: Immunotherapy has transformed treatment for patients with stage 4 metastatic esophageal and gastric cancers. In patients with these malignancies, immunotherapy has been shown to prolong survival when patients' tumors exhibit a high expression of an immune-related protein called PD-L1.

Researchers are now investigating whether immunotherapy benefits patients who do not have stage 4 metastatic disease. In these patients, tumors have not spread to distant organs. A study highlighting this research is published in Clinical Cancer Research.

"The current standard of care for patients with nonmetastatic gastroesophageal cancer involves preoperative chemotherapy plus radiation and subsequent surgical resection of the primary cancer and surrounding lymph nodes," says Harry Yoon, M.D., a medical oncologist at Mayo Clinic Cancer Center. However, Dr. Yoon notes that the rate of cancer recurrence in these patients is high, and if the tumor returns, the cancer is usually not curable.

Dr. Yoon and his colleagues performed a clinical trial to evaluate whether adding an immunotherapy called pembrolizumab to standard chemoradiation and surgery for patients with gastroesophageal junction adenocarcinoma might increase the number of patients who experienced complete tumor eradication in the original location and in nearby lymph nodes.

"Patients who experience this complete eradication appear to have a higher chance of cure," says Dr. Yoon. "We found that adding immunotherapy appeared to increase the likelihood of complete eradication of the primary tumor and regional nodal metastases in the group of patients whose tumors expressed high levels of PD-L1."

"If these results can be confirmed in a larger, separate clinical trial, the combination of immunotherapy with standard-of-care chemoradiation and surgery could become the new standard of care for patients with nonmetastatic gastroesophageal cancer," says Dr. Yoon

Dr. Yoon notes that a large national clinical trial supported by the National Cancer Institute (EA2174) is testing the combination of immunotherapy, chemoradiation and surgery in patients with nonmetastatic gastroesophageal cancer.

For more details, visit here:

https://doi.org/10.1158/1078-0432.ccr-22-0413

Clinical Cancer Research Immunotherapy cancer gastroesophageal cancer cancer treatment cancer patients tumor chemoradiotherapy nonmetastatic cancer prevention radiation 
Source : Clinical Cancer Research
Dr. Kamal Kant Kohli
Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as an Editor-in-Chief for the Speciality Medical Dialogues section. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Before Joining Medical Dialogues, he has served at important positions in the medical industry in India including as the Hony. Secretary of the Delhi Medical Association as well as the chairman of Anti-Quackery Committee in Delhi and worked with other Medical Councils in India. Email: editorial@medicaldialogues.in. Contact no. 011-43720751

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