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  • In-utero exposure of...

In-utero exposure of maternal thyroid disorders may increase thyroid cancer risk in kids

Hina ZahidWritten by Hina Zahid Published On 2021-01-25T23:00:20+05:30  |  Updated On 25 Jan 2021 5:30 PM GMT
In-utero exposure of maternal thyroid disorders may increase thyroid cancer risk in kids
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Thyroid cancer tends to be diagnosed at a younger age (median age 51 years) compared with most other malignancies (such as breast cancer [62 years] or lung cancer [71 years]). The incidence of thyroid cancer is higher in women than men diagnosed from early adolescence. However, few in-utero and early life risk exposures associated with increased risk of thyroid cancer have been...

Thyroid cancer tends to be diagnosed at a younger age (median age 51 years) compared with most other malignancies (such as breast cancer [62 years] or lung cancer [71 years]). The incidence of thyroid cancer is higher in women than men diagnosed from early adolescence. However, few in-utero and early life risk exposures associated with increased risk of thyroid cancer have been identified.

A recent study by prof. Tone Bjorge, University of Bergen, and her team shows that thyroid cancer is related to in-utero exposures.Maternal health and in utero exposures are associated with an increased risk for subsequent thyroid cancer in offspring, according to a study published online in The Lancet Diabetes & Endocrinology.

Thyroid cancer is diagnosed at a younger age than most other malignancies and the incidence is higher in women than men.

"The only established modifiable risk factors for thyroid cancer are childhood exposure to ionizing radiation and obesity. Few in-utero and early life risk factors have so far been identified" says Bjørge, professor at Department of Global Public Health and Primary Care, University of Bergen.

Maternal hypothyroidism, hyperthyroidism, goiter, and benign thyroid neoplasms related to higher risk

The team conducted a nested case-control study  using nationwide registry data from four Nordic countries (Denmark, Finland, Norway, and Sweden). The study included 2,437 thyroid cancer cases and 24,362 matched controls aged 0-48 years during 1967-2015.

"Maternal benign thyroid conditions such as hypothyroidism, hyperthyroidism, goiter, and benign thyroid neoplasms were strongly associated with thyroid cancer risk in offspring. Also, high birth weight, congenital hypothyroidism, maternal history of diabetes, and maternal postpartum haemorrhage were associated with increased risk", says Bjørge.

In-utero exposures, particularly those related to maternal thyroid disorders, might have a long-term influence on thyroid cancer risk in offspring.

Motivates further research

The study supports a link between in-utero exposures and an increased risk of thyroid cancer later in life.

"These findings should motivate additional research into early-life exposures that might cause thyroid cancer", says Bjørge.

https://www.thelancet.com/journals/landia/article/PIIS2213-8587(20)30399-5/fulltext


thyroid cancermaternal hypothyroidismmaternal postpartum haemorrhagein-uterothe lancetthyroid
Source : The Lancet
Hina Zahid
Hina Zahid

    Hina Zahid Joined Medical Dialogue in 2017 with a passion to work as a Reporter. She coordinates with various national and international journals and association and covers all the stories related to Medical guidelines, Medical Journals, rare medical surgeries as well as all the updates in the medical field. Email: editorial@medicaldialogues.in. Contact no. 011-43720751

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