Pre and Postoperative eGFR independent risk factor for CKD after Radical Nephrectomy

Written By : Dr.Niharika Harsha B |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-12-08T19:30:15+05:30 | Updated On 8 Dec 2022 7:30 PM IST

A new study found that preoperative estimated glomerular filtration rate (eGFR), age, and immediate postoperative eGFR are independent risk factors for postoperative chronic kidney disease. The study results were published in the journal BMC Cancer.

The most common treatment for localized renal cell carcinoma is radical nephrectomy (RN). Postoperative chronic kidney disease could result from the decreased number of nephrons due to RN. Hence researchers conducted a study to understand the incidence and risk factors for CKD in patients who have received RN.

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Between January 2010 to December 2018, at Zhejiang Provincial People's Hospital, a total of 1233 patients underwent radical nephrectomy. Patients with abnormal renal function before surgery or who were lost to follow-up were excluded from the study. Five hundred patients were enrolled and their eGFR was calculated using the abbreviated MDRD equation. CKD was defined as eGFR less than 60 ml/min/1.73m2. Kaplan-Meier method was used to estimate the incidence of postoperative CKD. logistic multivariate regression analysis was used to determine the independent risk factors for CKD.

Results:

Patients were followed up for a median of 40 months and CKD occurred in 189 cases.
The 5-year cumulative incidence of CKD was 43.4%.
Age, sex, weight, and preoperative eGFR(P<0.05) were significantly different between the 189 patients with CKD and the remaining patients without post-nephrectomy CKD.
Multivariate regression analysis showed that age, preoperative eGFR of the contralateral kidney, and Immediate postoperative eGFR were independent risk factors for postoperative CKD.

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The incidence of CKD after radical nephrectomy was common. The independent risk factors for postoperative CKD are age, preoperative eGFR of the contralateral kidney, and immediate postoperative eGFR.

Further reading: Wang, S., Liu, Z., Zhang, D. et al. The incidence and risk factors of chronic kidney disease after radical nephrectomy in patients with renal cell carcinoma. BMC Cancer 22, 1138 (2022). https://doi.org/10.1186/s12885-022-10245-8

Radical nephrectomyrenal cell carcinomachronic kidney diseaseestimated glomerular filtration rate (eGFR)CKDeGFRRNrisk factors

Source : BMC Cancer

Dr.Niharika Harsha B

BDS, MDS

Dr.Niharika Harsha B (BDS,MDS) completed her BDS from Govt Dental College, Hyderabad and MDS from Dr.NTR University of health sciences(Now Kaloji Rao University). She has 4 years of private dental practice and worked for 2 years as Consultant Oral Radiologist at a Dental Imaging Centre in Hyderabad. She worked as Research Assistant and scientific writer in the development of Oral Anti cancer screening device with her seniors. She has a deep intriguing wish in writing highly engaging, captivating and informative medical content for a wider audience. She can be contacted at editorial@medicaldialogues.in.

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751