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  • Vitamin D can mitigate...

Vitamin D can mitigate chemotherapy induced gastrointestinal mucositis

Dr. Kamal Kant KohliWritten by Dr. Kamal Kant Kohli Published On 2020-06-19T11:15:13+05:30  |  Updated On 19 Jun 2020 9:39 AM GMT
Vitamin D can mitigate chemotherapy induced gastrointestinal mucositis
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Vitamin D can mitigate chemotherapy induced gastrointestinal mucositis, finds a new study that has appeared in the journal Supportive and Palliative Care.Chemotherapy prescribed to kill the cancer cells is often more debilitating than the cancer itself.Gastrointestinal mucositis is a painful inflammation and ulceration of the digestive tract that is a troublesome adverse outcome of...

Vitamin D can mitigate chemotherapy induced gastrointestinal mucositis, finds a new study that has appeared in the journal Supportive and Palliative Care.

Chemotherapy prescribed to kill the cancer cells is often more debilitating than the cancer itself.

Gastrointestinal mucositis is a painful inflammation and ulceration of the digestive tract that is a troublesome adverse outcome of chemotherapy for which no effective treatment currently exists.

But this bleak outlook may be about to change, according to University of South Australia researchers who say Vitamin D could potentially mitigate inflamed intestinal tracts and provide relief to cancer patients.

A new study undertaken by Dr Andrea Stringer, Associate Professor Paul Anderson and PhD student Cyan Sylvester highlights the limited options for easing the gastrointestinal side effects of chemotherapy, singling out Vitamin D and probiotics as the most promising.

"We already know that Vitamin D helps in the absorption of calcium, but new findings suggest it may also play an important role in chemotherapy-induced intestinal mucositis," says Sylvester, the lead author of a recent paper reviewing new therapeutic strategies for combatting gastrointestinal toxicity.

"The severity and progression of various gastrointestinal diseases, such as irritable bowel syndrome and colorectal cancer, is associated with Vitamin D deficiency," she says. "It appears that Vitamin D helps suppress inflammation and enhances the function of T-cells which boosts immunity."

Vitamin D is also thought to improve the efficacy of certain anti-cancer drugs.

The researchers are now working on ways to enhance the activity of vitamin D in the intestine as a more viable option for treating gastrointestinal mucositis.

"We know that Vitamin D definitely does more than help absorb calcium, but we need to better understand and optimise its action in the gut before we can be 100 per cent confident that it could be a treatment option for gastrointestinal mucositis," says Dr Stringer.

"We are investigating the effects of enhanced vitamin D activity in the intestine on both reducing damage and minimising compositional change to the gut microbiome caused by chemotherapy agents."

Probiotics (live bacteria and yeast) have also been widely promoted for digestive health and there is evidence they reduce the severity of diarrhoea and abdominal pain, but researchers have not been able to establish the direct effect of probiotics on intestinal function that reduces these side effects during and following cancer treatment.

"Vitamin D shows the most promise and could prove the key hormone to alleviate suffering for cancer patients," Dr Stringer says.

For further reference log on to:

Current Opinion in Supportive and Palliative Care: June 2020 - Volume 14 - Issue 2 - p 142-152

doi: 10.1097/SPC.0000000000000500

CancerChemotherapygastrointestinal mucositisVitamin Dchemotherapy induced gastrointestinal mucositisvit d
Source : Supportive and Palliative Care
Dr. Kamal Kant Kohli
Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Before Joining Medical Dialogues, he has served at important positions in the medical industry in India including as the Hony. Secretary of the Delhi Medical Association as well as the chairman of Anti-Quackery Committee in Delhi and worked with other Medical Councils in India. Email: editorial@medicaldialogues.in. Contact no. 011-43720751

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