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  • A novel drop regimen...

A novel drop regimen reduces ocular hypertension risk after pars plana vitrectomy

Written By : Aditi |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2023-01-27T20:00:17+05:30  |  Updated On 27 Jan 2023 8:00 PM IST
A novel drop regimen reduces ocular hypertension risk after pars plana vitrectomy
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UK: According to a research article published in Ophthalmologica, researchers have pointed out that following pars plana vitrectomy (PPV), drop regimen of one-week dexamethasone 0.1%/antibiotic and one-month ketorolac is as effective as an anti-inflammatory. This regime is safer for Ocular hypertension (OHT) compared to standard care one-month dexamethasone 0.1%.

It is already known that postoperative steroid/antibiotic drop regimens effectively suppress inflammation and infection following Pars Plana Vitrectomy. However, steroid induces OHT frequently. This requires additional treatment and more frequent hospital visits in the postoperative period.

To address the concern mentioned above, a cohort-control study was conducted led by Orlans et al. to assess the safety and efficacy of a novel post-PPV drop regimen.

The study points are:

· The relevant electronic case notes were reviewed between December 2020-April 2021 of those patients who underwent PPV.

· The study was conducted at Vitreoretinal Service, St. Thomas' Hospital, London, UK

· The intervention cohort had 58 (28 %) patients given postoperative drops of one-week dexamethasone 0.1%/antibiotic QDS and one-month g. ketorolac TDS.

· Standard care controls included 151 (72 %) patients who received one-month g. dexamethasone 0.1%/antibiotic QDS.

· Total of 209 eyes from 192 patients were included.

· IOP≥30 mmHg two weeks postoperatively was the primary outcome measured by the researchers.

· Secondary outcomes were rates of anterior uveitis, cystoid macular oedema, endophthalmitis, and the number of eye hospital visits.

· Similarities were reported between baseline and <72hr postoperative IOPs between groups.

· IOP ≥ 30 mmHg at the two-week postoperative visit (primary outcome measure) occurred in none of the intervention groups but in 21 (14%) of the controls.

· The difference in IOP change distribution between the two groups was highly significant.

· There was no significant difference reported in secondary outcomes between the groups.

· There were no cases of endophthalmitis in either cohort.

· The intervention cohort had fewer all-cause eye hospital visits in the three months immediately following PPV.

The novel regimen used in the study reduced rate of subsequent OHT, a lesser need for additional topical antihypertensive treatment, and fewer patient visits to the eye hospital in the postoperative period.

Further reading:

Orlans HO, Yazdouni S, Williamson TH, Wong RS, Laidlaw DAH. A novel postoperative drop regimen reduces the risk of ocular hypertension following pars plana vitrectomy. Ophthalmologica. 2022 Dec 23. DOI: 10.1159/000528037


novel drop regimenocular hypertensionOphthalmologicadexamethasoneketorolac
Source : Ophthalmologica
Aditi
Aditi

    BDS, MDS in Periodontics and Implantology

    Dr. Aditi Yadav is a BDS, MDS in Periodontics and Implantology. She has a clinical experience of 5 years as a laser dental surgeon. She also has a Diploma in clinical research and pharmacovigilance and is a Certified data scientist. She is currently working as a content developer in e-health services. Dr. Yadav has a keen interest in Medical Journalism and is actively involved in Medical Research writing.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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