CKD closely linked to choroidal effusions after glaucoma surgery: Study
CAPTION
Researchers have developed a potential new treatment for the eye disease glaucoma that could replace daily eye drops and surgery with a twice-a-year injection to control the buildup of pressure in the eye.
CREDIT
Rob Felt, Georgia Tech
USA: A recent study in the Journal of Glaucoma showed chronic kidney disease (CKD) to be substantially linked with choroidal effusion after glaucoma surgery.
Previous studies have shown that patients with chronic kidney disease (CKD) are more likely to develop choroidal effusions after glaucoma surgery. Choroidal effusion is glaucoma surgical postoperative complication caused by a transudative fluid accumulation in the suprachoroidal region. Kidney illness changes the fluid dynamics of the body through a variety of methods. There has previously been no research into the relationship between CKD and choroidal effusion following glaucoma surgery.
This study was conducted by Richard L. Ford and the team with the objective to see if there was a link between CKD and the development of choroidal effusions after glaucoma surgery.
This study included 86 eyes from 86 individuals who had glaucoma filtering surgery or transscleral cyclophotocoagulation throughout the study period. There were 43 individuals with CKD and 43 people who did not have renal disease. The primary finding of this study was the development of choroidal effusion, as evaluated by the Pearson 2 test and multivariate analysis with a binomial regression with a log link.
The key findings of this study are as follows:
1. Ten patients (23.3%) in the CKD group experienced choroidal effusion, compared to two patients (4.7%) in the no-kidney disease group (relative risk, 5.0).
2. In the multivariate study, the connection between CKD and choroidal effusion yielded conflicting findings, with some studies revealing a significant association and others showing no significant association.
In conclusion, the relationship between chronic kidney disease (CKD) and the development of choroidal effusions in individuals following glaucoma surgery was investigated in this retrospective cohort research. When compared to individuals without CKD, CKD imparted a 5-fold relative risk (RR) for choroidal effusion after glaucoma surgery. Furthermore, when age (4.40), Ahmed glaucoma valve implantation, and neovascular glaucoma (5.47) were taken into account, multivariate analysis indicated an RR of choroidal effusion in individuals with CKD.
These findings might aid in the counseling of CKD patients regarding the risk of choroidal effusion, as well as giving predictive variables for the development of choroidal effusion after glaucoma surgery, added the authors.
Reference:
Ford, R. L., Klifto, M. R., Knight, O. J., Jain, K., Wiesen, C., & Fleischman, D. (2021). Chronic Kidney Disease as a Predictor of Postoperative Choroidal Effusions After Glaucoma Surgery. In Journal of Glaucoma (Vol. 30, Issue 11, pp. 981–987). Ovid Technologies (Wolters Kluwer Health). https://doi.org/10.1097/ijg.0000000000001908
