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  • Corneal Changes linked...

Corneal Changes linked to severity of disease activity in rheumatoid arthritis patients

Written By : Aditi |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2023-11-26T19:00:10+05:30  |  Updated On 27 Nov 2023 10:50 AM IST
Corneal Changes linked to severity of disease activity in rheumatoid arthritis patients
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Rheumatoid arthritis is an autoimmune disorder that affects multiple systems in the body and has articular and extra-articular manifestations. Although neuropathy, or nerve damage, has been observed as a complication of RA, it is not well understood and has limited research attention.

A study found that patients with Rheumatoid arthritis had reduced corneal sensitivity, a loss of corneal nerve fibers, and an increase in Langerhans cells, which were all linked to the severity of their disease activity, Says Dr Gulfidan Bitirgen and colleagues in their recent study published in Eye.

This cross-sectional study included 50 RA patients and 35 healthy controls. It was conducted at a university hospital. It assessed disease activity with a 28-Joint Disease Activity Score and erythrocyte sedimentation rate or DAS28-ESR and central corneal sensitivity with a Cochet-Bonnet contact corneal esthesiometer. Corneal nerve fibre density, branch density, length, and Langerhans cell density were measured using a confocal microscope.

This study employed corneal confocal microscopy to determine if there is any indication of small nerve fibre damage and immune cell activation in individuals with rheumatoid arthritis (RA).

Key findings from the study are:

  • Corneal sensitivity, corneal nerve fibre density (CNFD), nerve branch density (CNBD) and nerve fibre length (CNFL) were lower, and mature and immature Langerhans cell (LC) densities were higher in RA patients than in control subjects.
  • CNFD and CNFL were lower in patients with moderate to high (DAS28-ESR > 3.2) compared to mild (DAS28-ESR ≤ 3.2) disease activity.
  • DAS28-ESR score correlated with CNFD (r = −0.425), CNBD (ρ = −0.362), CNFL (r = −0.464), total LC density (ρ = 0.362) and immature LC density (ρ = 0.343).

Our study demonstrated reduced corneal sensitivity, corneal nerve fibre loss and increased Langerhans cells, which were associated with the severity of disease activity in rheumatoid arthritis patients.

The work was supported by The Scientific Research Coordination Center of Necmettin Erbakan, as acknowledged.

Reference:

Bitirgen, G., Kucuk, A., Ergun, M.C. et al. Corneal nerve loss and increased Langerhans cells are associated with disease severity in patients with rheumatoid arthritis. Eye 37, 2950–2955 (2023). https://doi.org/10.1038/s41433-023-02447-6



corneal changesdisease activityrheumatoid arthritisEye Journal
Source : EYE
Aditi
Aditi

    BDS, MDS in Periodontics and Implantology

    Dr. Aditi Yadav is a BDS, MDS in Periodontics and Implantology. She has a clinical experience of 5 years as a laser dental surgeon. She also has a Diploma in clinical research and pharmacovigilance and is a Certified data scientist. She is currently working as a content developer in e-health services. Dr. Yadav has a keen interest in Medical Journalism and is actively involved in Medical Research writing.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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