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  • COVID-19 Found in The...

COVID-19 Found in The Cornea: Are Transplants a Transmission Risk?

Written By : Hina Zahid |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2020-12-28T15:30:27+05:30  |  Updated On 28 Dec 2020 3:30 PM IST
COVID-19 Found in The Cornea: Are Transplants a Transmission Risk?
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COVID-19 has been found in conjunctival swabs and tears of infected patients, according to a new study published in The Ocular Surface.

The discovery prompted a research team including Shahzad Mian, M.D., an ophthalmologist at Kellogg Eye Center, to analyze the prevalence of COVID-19 in human post-mortem ocular tissues. The results: the virus can infiltrate corneal tissue, the clear, outer layer of the eye, that could be used for transplantation in the U.S., raising concerns that the disease could be transmitted to a healthy recipient.

Of the 132 ocular tissues from 33 donors intended for surgery in Michigan, Illinois, Ohio and New Jersey, 13% were positive for COVID-19, which was determined by isolating the ribonucleic acid (RNA), a molecule similar to DNA, of the patients that were known to have the virus or showed symptoms without a positive nasopharyngeal swab.

Studies have shown that COVID-19 patients hold much of the virus in the upper respiratory tract, so there's a strong possibility the virus could contaminate the outer layers of the eye via respiratory droplets after coughing, sneezing or hand-to-eye contact, according to Mian.

"There's no evidence to suggest COVID-19 can be transmitted from a corneal transplant, but our data assures us that a screening process to determine who's positive for the virus and who isn't is important to make sure we do everything in case there is a potential risk of transmission," Mian adds.

The findings also demonstrate the critical importance of post-mortem nasopharyngeal swab testing for detecting COVID-19 before transplantation. The study's donors were divided into three groups:

  • Group 1

This group was positive for COVID-19 after receiving a nasopharyngeal swab at the time of corneal recovery.

  • Group 2

This group was primarily made up of donors from early in the pandemic when testing wasn't widely available. The majority of these donors had a negative COVID-19 test.

  • Group 3

This group didn't have signs or symptoms of COVID-19 and tested negative, but they also spent extended amounts of time with someone who tested positive.

This is significant because 15% of the corneal samples from Group 2 presented with COVID-19 RNA, despite having a negative nasopharyngeal swab test. In fact, this was even higher than the presence of coronavirus-infected corneal tissue from Group 1, which only had a positivity rate of 11% despite the donors having positive nasopharyngeal swab tests.

None of the tissues from Group 3's two donors had a presence of COVID-19 RNA.

Lowering the presence of COVID-19 in the cornea

Aside from establishing a screening process, Mian set out to discover if there was a way to lower the presence of COVID-19 in the donor tissue -- another strategy that could diminish transmission risk.

"An initial study goal was to test the effectiveness of povidone-iodine, a disinfectant, in inactivating COVID-19," Mian says.

This was done by recovering donors' right eyes without cleaning with povidone-iodine and following the Eye Bank Association of America recommended double povidone-iodine soak procedure on the left eyes.

The procedure involves soaking the cornea in 5% povidone-iodine for five minutes, then flushing with sterile saline fluid. This is repeated after a sample of corneal tissue is harvested. All of the eyes that underwent this disinfecting tested negative for COVID-19 RNA, compared to one of the right eye swabs that tested positive.

However, the team is unable to conclude that povidone-iodine is at all effective in reducing COVID-19 in corneal tissue because this procedure was only performed on 10 patients.

"A larger study is needed to confirm our findings, but we're excited about this research's potential implications. These questions are important in keeping our patients healthy and safe," Mian says.

It's unclear whether the presence of COVID-19 RNA is due to ocular surface infection or due to transport of the virus from the upper respiratory tract via the tear ducts. It's also unclear whether COVID-19 can replicate in corneal cells and what changes occur in these cells when infected.

"The takeaway I hope other physicians have when reading this study is that following elaborate donor screening procedures to mitigate the risk of pathogen transmission during transplant, as well as testing post-mortem donors for COVID-19 specifically, when there is no COVID-19 nasal swab testing, is critically important as professionals in this field.

https://www.sciencedirect.com/science/article/pii/S1542012420301683?via%3Dihub


the ocular surfacecovid-19coronaviruscorneaconjunctival swabspost-mortem ocular tissues.ribonucleic acidnasopharyngeal swab
Source : The Ocular Surface.
Hina Zahid
Hina Zahid

    Hina Zahid Joined Medical Dialogue in 2017 with a passion to work as a Reporter. She coordinates with various national and international journals and association and covers all the stories related to Medical guidelines, Medical Journals, rare medical surgeries as well as all the updates in the medical field. Email: editorial@medicaldialogues.in. Contact no. 011-43720751

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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