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  • Development of global...

Development of global innovative drug in eye drop form for treating dry age-related macular degeneration

Dr. Kamal Kant KohliWritten by Dr. Kamal Kant Kohli Published On 2024-12-25T20:30:34+05:30  |  Updated On 26 Dec 2024 11:04 AM IST
CDSCO nod to ENTOD Pharma new eye drop to slow Myopia progression in children
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Age related macular degeneration (AMD) is the leading cause of vision loss in individuals over 65, characterized by abnormal changes in the macular, resulting in reduced vision and distorted objects. Dry AMD accounts for 90% of all AMD cases, with relatively mild vision impairment; however, approximately 30% progress to the severe vision loss associated with wet AMD within 10 years. The only FDA-approved treatments for dry AMD as of 2023 are two injectable drugs, which are limited by concerns over complications from intravitreal injections and modest efficacy in restoring vision.

The research team led by Dr. Moon-Hyeong Seo from the Natural Product Drug Development Center at the Korea Institute of Science and Technology (KIST, President Oh Sang-Rok) has developed a new therapeutic agent for dry AMD that can be administered as eye drops. Eye drops are the most preferred drug delivery method in the ophthalmic market, yet developing eye drop formulations targeting the retina, located in the posterior segment of the eye, remains a significant challenge.

To address the limitations of injection-based treatments, the research team focused on the inflammatory signaling pathway of Toll-like receptors (TLRs), which are known to play a critical role in AMD pathogenesis. By extracting peptide sequences from tens of thousands of proteins with structures similar to natural TLR signaling proteins, they established an extensive library of over 190,000 peptide drug candidates. Utilizing advanced technology for rapidly screening peptides that specifically bind to TLR signaling proteins, they successfully identified multiple candidate peptides capable of inhibiting interactions between these proteins.

The researchers validated the therapeutic efficacy of the peptides by administering them as eye drops to mice with induced dry AMD. The treated group exhibited retinal cell protection and significantly reduced retinal degeneration, comparable to normal mice. This demonstrated that peptide-based eye drops could effectively replace existing injectable therapies for dry AMD.

This new therapeutic agent, delivered in eye drop form, offers enhanced treatment convenience and adherence for patients while reducing complications and costs associated with repetitive invasive treatments. Furthermore, the non-invasive and safe nature of the therapy provides a novel treatment option that improves both efficacy and patient satisfaction. This innovation is expected to revolutionize the treatment accessibility of AMD and other related ophthalmic conditions.

Dr. Seo stated, “The KIST Natural Product Drug Development Center, established in September to focus on mission-driven research, aims to develop global drugs targeting aging-related diseases, including cancer and ophthalmic conditions. We plan to pursue collaborative research with domestic and international pharmaceutical companies to advance global clinical trials for this innovative dry AMD therapeutic.”

Reference:

Yun Lim, Tae Kyeom Kang, Meong Il Kim, Dohyeon Kim, Ji Yul Kim, Sang Hoon Jung, Keunwan Park, Wook-Bin Lee, Moon-Hyeong Seo, Massively Parallel Screening of Toll/Interleukin-1 Receptor (TIR)-Derived Peptides Reveals Multiple Toll-Like Receptors (TLRs)-Targeting Immunomodulatory Peptides, Advanced Science, https://doi.org/10.1002/advs.202406018

Advanced Scienceage related macular degenerationvision loss
Source : Advanced Science
Dr. Kamal Kant Kohli
Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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